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01-08-2015 | Neurology and Preclinical Neurological Studies - Review Article

Vascular cognitive impairment, dementia, aging and energy demand. A vicious cycle

Authors: A. Popa-Wagner, Ana-Maria Buga, B. Popescu, D. Muresanu

Published in: Journal of Neural Transmission | Special Issue 1/2015

Abstract

To a great extent, cognitive health depends on cerebrovascular health and a deeper understanding of the subtle interactions between cerebrovascular function and cognition is needed to protect humans from one of the most devastating affliction, dementia. However, the underlying biological mechanisms are still not completely clear. Many studies demonstrated that the neurovascular unit is compromised in cerebrovascular diseases and also in other types of dementia. The hemodynamic neurovascular coupling ensures a strong increase of the cerebral blood flow (CBF) and an acute increase in neuronal glucose uptake upon increased neural activity. Dysfunction of cerebral autoregulation with increasing age along with age-related structural and functional alterations in cerebral blood vessels including accumulation of amyloid-beta (Aβ) in the media of cortical arterioles, neurovascular uncoupling due to astrocyte endfeet retraction, impairs the CBF and increases the neuronal degeneration and susceptibility to hypoxia and ischemia. A decreased cerebral glucose metabolism is an early event in Alzheimer’s disease (AD) pathology and may precede the neuropathological Aβ deposition associated with AD. Aβ accumulation in turn leads to further decreases in the CBF closing the vicious cycle. Alzheimer, aging and diabetes are also influenced by insulin/insulin-like growth factor-1 signaling, and accumulated evidence indicates sporadic AD is associated with disturbed brain insulin metabolism. Understanding how vascular and metabolic factors interfere with progressive loss of functional neuronal networks becomes essential to develop efficient drugs to prevent cognitive decline in elderly.

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Title: Vascular cognitive impairment, dementia, aging and energy demand. A vicious cycle
Authors: A. Popa-Wagner
Ana-Maria Buga
B. Popescu
D. Muresanu
Publication date: 01-08-2015
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue Special Issue 1/2015
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-013-1129-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Vascular cognitive impairment, dementia, aging and energy demand. A vicious cycle

Abstract

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Abstract

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