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Journal of Neural Transmission
Published in: Journal of Neural Transmission 4/2013

01-04-2013 | Neurology and Preclinical Neurological Studies - Review Article

Effect of subthalamic deep brain stimulation on non-motor fluctuations in Parkinson’s disease

Authors: Jean-Philippe Azulay, Tatiana Witjas, Alexandre Eusebio

Published in: Journal of Neural Transmission | Issue 4/2013

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Abstract

The non-motor consequences of subthalamic stimulation are largely questioned. Cognition, motivation, anxiety, depression and even occurrence of suicides have been considered as a potential consequence of the surgical intervention. Non-motor fluctuations are present in all the patients with motor fluctuations and may sometimes be even more invalidating. Interestingly, subthalamic deep brain stimulation alleviates non-motor fluctuations allowing strikingly successful effects on sensory, dysautonomic and cognitive fluctuations while psychic fluctuations respond less consistently to this treatment. Nevertheless, severe mood fluctuations, oscillating from Off dysphoria to ON hypomania, are frequently associated with addictive behaviors and improve dramatically after subthalamic stimulation. This may be a further argument to support the indication of surgery for these patients.
Literature
Ardouin C, Pillon B, Peiffer E et al (1999) Bilateral subthalamic or pallidal stimulation for Parkinson’s disease affects neither memory nor executive functions: a consecutive series of 62 patients. Ann Neurol 46:217–223PubMedCrossRef
Borgohain R, Kandadai RM, Jabeen A, Kannikannan MA (2012) Nonmotor outcomes in Parkinson’s disease: is deep brain stimulation better than dopamine replacement therapy? Ther Adv Neurol Disord 5(1):23–41PubMedCrossRef
Gunal DI, Nurichalici K, Tuncer N, Bekiroglu N, Aktan S (2002) The Clinical profile of non motor fluctuations in Parkinson’s disease patients. Can J Neurol Sci 29:61–64PubMedCrossRef
Houeto JL, Mesnage V, Mallet L et al (2002) Behavioural disorders, Parkinson’s disease and subthalamic stimulation. J Neurol Neurosurg Psychiatry 72:701–707PubMedCrossRef
Kleiner-Fisman G, Herzog J, Fisman DN, Tamma F, Lyons KE, Pahwa R, Lang AE, Deuschl G (2006) Subthalamic nucleus deep brain stimulation: summary and meta-analysis of outcomes. Mov Disord 21(Suppl 14):S290–S304
Kleiner-Fisman G, Martine R, Lang AE, Stern MB (2011) Development of a non-motor fluctuation assessment instrument for Parkinson disease. Parkinsons Dis 2011:292719
Krack P, Batir A, Van Blercom N et al (2003) Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson’s disease. N Engl J Med 349(54):1925–1934PubMedCrossRef
Lhommée E, Klinger H, Thobois S, Schmitt E, Ardouin C, Bichon A, Kistner A, Fraix V, Xie J, Aya Kombo M, Chabardès S, Seigneuret E, Benabid AL, Mertens P, Polo G, Carnicella S, Quesada JL, Bosson JL, Broussolle E, Pollak P, Krack P (2012) Subthalamic stimulation in Parkinson’s disease: restoring the balance of motivated behaviours. Brain 135(Pt 5):1463–1477PubMedCrossRef
Morrison CE, Borod JC, Perrine K et al (2004) Neuropsychological functioning following bilateral subthalamic nucleus stimulation in Parkinson’s disease. Arch Clin Neuropsychol 19:165–181PubMedCrossRef
Riley DE, Lang AE (1993) The spectrum of Levodopa-related fluctuations in Parkinson’s disease. Neurology 43:1495–1496
Saint-Cyr JA, Trepanier LL, Kumar R, et al (2000) Neuropsychological consequences of chronic bilateral stimulation of the subthalamic nucleus in Parkinson’s disease. Brain 123 (Part 10):2091–2108
Schupbach WM, Chastan N, Welter ML et al (2005) Stimulation of the subthalamic nucleus in Parkinson’s disease: a 5 year follow up. J Neurol Neurosurg Psychiatry 76:1640–1644PubMedCrossRef
Stacy M, Bowron A, Guttman M, Hauser R, Hughes K, Larsen JP, LeWitt P, Oertel W, Quinn N, Sethi K, Stocchi F (2005) Identification of motor and nonmotor wearing-off in Parkinson’s disease: comparison of a patient questionnaire versus a clinician assessment. Mov Disord 20(6):726–733PubMedCrossRef
Witjas T, Kaplan E, Azulay JP (2002) Nonmotor fluctuations in Parkinson’s disease: frequent and disabling. Neurology 59:408–413PubMedCrossRef
Witjas T, Kaphan E, Régis J, Jouve E, Chérif AA, Péragut JC, Azulay JP (2007) Effects of chronic subthalamic stimulation on nonmotor fluctuations in Parkinson’s disease. Mov Disord 22(12):1729–1734PubMedCrossRef
Wooten GF (1988) Progress in understanding the pathology of treatment-related fluctuations in Parkinson’s disease. Ann Neurol 24:363–365PubMedCrossRef
Metadata
Title
Effect of subthalamic deep brain stimulation on non-motor fluctuations in Parkinson’s disease
Authors
Jean-Philippe Azulay
Tatiana Witjas
Alexandre Eusebio
Publication date
01-04-2013
Publisher
Springer Vienna
Published in
Journal of Neural Transmission / Issue 4/2013
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-012-0958-9

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