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01-12-2012 | Neurology and Preclinical Neurological Studies - Review article

Considerations for measuring iron in post-mortem tissue of Parkinson’s disease patients

Authors: Dominic J. Hare, Manfred Gerlach, Peter Riederer

Published in: Journal of Neural Transmission | Issue 12/2012

Abstract

Redox-active iron is considered to be an important factor in the pathology and progression of several neurodegenerative disorders, including Parkinson’s disease. The various roles of iron in normal physiology and its prevalence in the wider environment present numerous challenges to both accurate measurement and interpretation of brain iron levels. This review will discuss considerations for the analysis of iron in post-mortem samples, including how contamination, sample preparation and methods of analysis may influence results. In addition, several important factors influencing interpretation of iron levels will be considered.

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Title: Considerations for measuring iron in post-mortem tissue of Parkinson’s disease patients
Authors: Dominic J. Hare
Manfred Gerlach
Peter Riederer
Publication date: 01-12-2012
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 12/2012
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-012-0898-4

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Considerations for measuring iron in post-mortem tissue of Parkinson’s disease patients

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