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01-10-2011 | Movement Disorders - Original Article

Pedunculopontine stimulation from primate to patient

Authors: Erlick A. C. Pereira, Dipankar Nandi, Ned Jenkinson, John F. Stein, Alexander L. Green, Tipu Z. Aziz

Published in: Journal of Neural Transmission | Issue 10/2011

Abstract

Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson’s disease and related disorders. Here we summarise our non-human primate investigations of relevance to our surgical targeting of the PPN and relate the primate research to initial clinical experience of PPN DBS.

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Title: Pedunculopontine stimulation from primate to patient
Authors: Erlick A. C. Pereira
Dipankar Nandi
Ned Jenkinson
John F. Stein
Alexander L. Green
Tipu Z. Aziz
Publication date: 01-10-2011
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 10/2011
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-011-0631-8

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Pedunculopontine stimulation from primate to patient

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