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01-07-2009 | Basic Neurosciences, Genetics and Immunology - Original Article

Functional gene variants of the serotonin-synthesizing enzyme tryptophan hydroxylase 2 in migraine

Authors: Martin Marziniak, Claudia Kienzler, Gregor Kuhlenbäumer, Claudia Sommer, Rainald Mössner

Published in: Journal of Neural Transmission | Issue 7/2009

Abstract

Serotonin (5-HT) plays an important role in the pathophysiology of migraine. Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in the biosynthesis of 5-HT in the brain and is therefore a major factor in the availability of 5-HT and its rate of production. We hypothesized that functional TPH2 gene variants are associated with migraine. In a case–control study approach, two proven functional and two putatively functional variants of the TPH2 gene were investigated in 266 migraine patients and 153 controls. Genotype, allele, and haplotype frequencies did not differ between healthy subjects and migraineurs. A subgroup analysis for the occurrence of aura or clinical characteristics, including the number of attacks, did not reveal a positive association for the investigated polymorphisms. Our data argue against a major influence of the TPH2 gene promoter region in migraine.

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Title: Functional gene variants of the serotonin-synthesizing enzyme tryptophan hydroxylase 2 in migraine
Authors: Martin Marziniak
Claudia Kienzler
Gregor Kuhlenbäumer
Claudia Sommer
Rainald Mössner
Publication date: 01-07-2009
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 7/2009
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-009-0236-7

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Functional gene variants of the serotonin-synthesizing enzyme tryptophan hydroxylase 2 in migraine

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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