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Open Access 01-02-2009 | Parkinson's Disease and Allied Conditions - Original Article

MEG resting state functional connectivity in Parkinson’s disease related dementia

Authors: J. L. W. Bosboom, D. Stoffers, E. Ch. Wolters, C. J. Stam, H. W. Berendse

Published in: Journal of Neural Transmission | Issue 2/2009

Abstract

Parkinson’s disease (PD) related dementia (PDD) develops in up to 60% of patients, but the pathophysiology is far from being elucidated. Abnormalities of resting state functional connectivity have been reported in Alzheimer’s disease (AD). The present study was performed to determine whether PDD is likewise characterized by changes in resting state functional connectivity. MEG recordings were obtained in 13 demented and 13 non-demented PD patients. The synchronization likelihood (SL) was calculated within and between cortical areas in six frequency bands. Compared to non-demented PD, PDD was characterized by lower fronto-temporal SL in the alpha range, lower intertemporal SL in delta, theta and alpha1 bands as well as decreased centro-parietal gamma band synchronization. In addition, higher parieto-occipital synchronization in the alpha2 and beta bands was found in PDD. The observed changes in functional connectivity are reminiscent of changes in AD, and may reflect reduced cholinergic activity and/or loss of cortico-cortical anatomical connections in PDD.

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Title: MEG resting state functional connectivity in Parkinson’s disease related dementia
Authors: J. L. W. Bosboom
D. Stoffers
E. Ch. Wolters
C. J. Stam
H. W. Berendse
Publication date: 01-02-2009
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 2/2009
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-008-0132-6

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MEG resting state functional connectivity in Parkinson’s disease related dementia

Abstract

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Abstract

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