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01-05-2008 | Parkinson's Disease and Allied Conditions - Short Communication

Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson’s disease patients

Authors: Mariangela Pierantozzi, Maria Giuseppina Palmieri, Salvatore Galati, Paolo Stanzione, Antonella Peppe, Domenicantonio Tropepi, Livia Brusa, Antonio Pisani, Vincenzo Moschella, Maria Grazia Marciani, Paolo Mazzone, Alessandro Stefani

Published in: Journal of Neural Transmission | Issue 5/2008

Abstract

Bilateral peduncolopontine nucleus (PPN) and subthalamic nucleus (STN) deep brain stimulation (DBS) was performed in six-advanced Parkinson’s disease (PD) patients. We report the effect of both PPN-DBS (25 Hz) and STN-DBS (185 Hz) on patient spinal reflex excitability by utilizing the soleus-Hoffman reflex (HR) threshold. Compared to controls (n = 9), patients showed an increase of HR-threshold, which was scarcely affected by levodopa, but significantly reduced by DBS. In particular, we found that PPN-DBS alone, or plus STN-DBS induced a complete recovery of HR-threshold up to control values. The HR-threshold changes, although do not allow to investigate the contribution of specific intraspinal pathways, suggest that PPN may play a key-role in modulating spinal excitability in PD possibly by improving the basal ganglia-brainstem descending system activity.

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Title: Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson’s disease patients
Authors: Mariangela Pierantozzi
Maria Giuseppina Palmieri
Salvatore Galati
Paolo Stanzione
Antonella Peppe
Domenicantonio Tropepi
Livia Brusa
Antonio Pisani
Vincenzo Moschella
Maria Grazia Marciani
Paolo Mazzone
Alessandro Stefani
Publication date: 01-05-2008
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 5/2008
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-007-0001-8

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Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson’s disease patients

Abstract

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