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Acta Neurochirurgica
Published in: Acta Neurochirurgica 4/2021

01-04-2021 | Chondrosarcoma | Original Article - Tumor - Other

Gamma Knife Stereotactic Radiosurgery for the treatment of chordomas and chondrosarcomas

Authors: Julian Cahill, Ramez Ibrahim, Geza Mezey, John Yianni, Debapriya Bhattacharyya, Lee Walton, Alison Grainger, Matthias W. R. Radatz

Published in: Acta Neurochirurgica | Issue 4/2021

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Abstract

Introduction

Primary chordomas and chondrosarcomas of the skull base are difficult tumours to treat successfully. Despite advances in surgical techniques, a gross total resection is often impossible to achieve. In addition, some patients may be deemed unsuitable or not wish to undergo extensive surgery for these conditions. This study examines the role of Gamma Knife Stereotactic Radiosurgery (GKRS) in the treatment of these difficult cases.

Methods

All patients harbouring either a chordoma or chondrosarcoma treated at the National Centre for Stereotactic Radiosurgery, Royal Hallamshire Hospital, Sheffield, UK, between 1985 and 2018, were reviewed with regard to their clinical presentations, pre- and post-treatment imaging, GKRS prescriptions and outcomes.

Results

In total, 24 patients with a mean tumour volume of 13 cm3 in the chordoma group (n=15) and 12 cm3 in the chondrosarcoma group (n=9) underwent GKRS. The 5- and 10-year overall survival rates for the chordoma group were 67% and 53% respectively, while for the chondrosarcoma group, they were 78% at both time points. The tumour control rates at 5 and 10 years in the chordoma group were 67% and 49% and for the chondrosarcoma group 78% at both time points. Patients with tumour volumes of less than 7 cm3 before GKRS treatment demonstrated a statistically significant longer overall survival rate (p=0.03).

Conclusions

GKRS offers a comparable option to proton beam therapy for the treatment of these tumours. Early intervention for tumour volumes of less than 7 cm3 gives the best long-term survival rates.
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Metadata
Title
Gamma Knife Stereotactic Radiosurgery for the treatment of chordomas and chondrosarcomas
Authors
Julian Cahill
Ramez Ibrahim
Geza Mezey
John Yianni
Debapriya Bhattacharyya
Lee Walton
Alison Grainger
Matthias W. R. Radatz
Publication date
01-04-2021
Publisher
Springer Vienna
Keyword
Chondrosarcoma
Published in
Acta Neurochirurgica / Issue 4/2021
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-021-04768-5

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