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01-07-2020 | Multiple Sclerosis | Case Report

SARS-CoV-2 can induce brain and spine demyelinating lesions

Authors: Luca Zanin, Giorgio Saraceno, Pier Paolo Panciani, Giulia Renisi, Liana Signorini, Karol Migliorati, Marco Maria Fontanella

Published in: Acta Neurochirurgica | Issue 7/2020

Abstract

SARS-CoV-2 can attack the central nervous system in the early stages of infection. Headache, anosmia, and dysgeusia are common symptoms. Disturbance of consciousness and seizures can occur as complications in case of severe COVID-19. We described the case of a COVID-19 patient admitted for interstitial pneumonia and seizures. MRI showed newly diagnosed demyelinating lesions. High-dose steroid treatment allowed neurological and respiratory recovery. We speculated a delayed immune response induced by SARS-CoV-2. The virus may lead to a SIRS-like immune disorder or play a role of infective trigger. Prompt invasive treatment should be adopted to avoid hypoxic neurotoxicity and prevent CNS injuries.

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Title: SARS-CoV-2 can induce brain and spine demyelinating lesions
Authors: Luca Zanin
Giorgio Saraceno
Pier Paolo Panciani
Giulia Renisi
Liana Signorini
Karol Migliorati
Marco Maria Fontanella
Publication date: 01-07-2020
Publisher: Springer Vienna
Keywords: Multiple Sclerosis
SARS-CoV-2
Pneumonia
COVID-19
Anosmia
Published in: Acta Neurochirurgica / Issue 7/2020
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-020-04374-x

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SARS-CoV-2 can induce brain and spine demyelinating lesions

Abstract

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Abstract

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