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Acta Neurochirurgica

Published in:

01-02-2019 | Case Report - Brain Tumors

Disseminated central nervous system hemangioblastoma in a patient with no clinical or genetic evidence of von Hippel-Lindau disease—a case report and literature review

Authors: Simer J. Bains, Pitt F. Niehusmann, Torstein R. Meling, Cathrine Saxhaug, Mark Züchner, Petter Brandal

Published in: Acta Neurochirurgica | Issue 2/2019

Abstract

Background

Hemangioblastomas (HB) are benign tumors of the central nervous system (CNS) that can appear sporadic or as part of von Hippel-Lindau (VHL) disease. It is often curable with surgical resection, but upon relapse, the disease exhibits a treatment-refractory course.

Case report

A patient treated for sporadic cerebellar HB relapsed 12 years post-surgery. She developed disseminated disease throughout the CNS, including leptomeningeal manifestations. Repeat surgery and craniospinal radiation therapy were unsuccessful.

Conclusion

This case is in line with previous publications on disseminated non-VHL HB. Available treatment options are inefficient, emphasizing the need for improved understanding of HB biology to identify therapeutic targets.

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Title: Disseminated central nervous system hemangioblastoma in a patient with no clinical or genetic evidence of von Hippel-Lindau disease—a case report and literature review
Authors: Simer J. Bains
Pitt F. Niehusmann
Torstein R. Meling
Cathrine Saxhaug
Mark Züchner
Petter Brandal
Publication date: 01-02-2019
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 2/2019
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-019-03800-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Disseminated central nervous system hemangioblastoma in a patient with no clinical or genetic evidence of von Hippel-Lindau disease—a case report and literature review

Abstract

Background

Case report

Conclusion

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Springer Medicine

Abstract

Background

Case report

Conclusion

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