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01-06-2018 | Original Article - Brain Tumors

Tumor-treating fields as a fourth treating modality for glioblastoma: a meta-analysis

Authors: Dimitrios E. Magouliotis, Eftihia K. Asprodini, Konstantina A. Svokos, Vasiliki S. Tasiopoulou, Alexis A. Svokos, Steven A. Toms

Published in: Acta Neurochirurgica | Issue 6/2018

Abstract

Background

We aim to review the available literature on patients suffering from glioblastoma treated with tumor-treating fields (TTFields) plus radio chemotherapy or conventional radio chemotherapy alone, to compare the efficacy and safety of the two methods.

Methods

A systematic literature search was performed in PubMed, Cochrane library, and Scopus databases, in accordance with the PRISMA guidelines. Six studies met the inclusion criteria incorporating 1806 patients for the qualitative analysis and 1769 for the quantitative analysis.

Results

This study reveals increased median overall survival (weighted mean difference (WMD) 3.29 [95% confidence interval (CI) 2.37, 4.21]; p < 0.00001), survival at 1 year (odds ratio (OR) 1.81 [95% CI 1.41, 2.32]; p < 0.00001) and 2 years (OR 2.33 [95% CI 1.73, 3.14]; p < 0.00001), and median progression-free survival (WMD 2.35 [95% CI 1.76, 2.93]; p < 0.00001) along with progression-free survival at 6 months (WMD 6.86 [95% CI 5.91, 7.81]; p < 0.00001) for the patients treated with TTFields. Survival at 3 years was comparable between the two groups. TTFields were associated with fewer adverse events compared to chemotherapy along with similar incidence of skin irritation.

Conclusions

TTFields are a safe and efficient novel treatment modality. More randomized controlled studies, with longer follow-up, are necessary to further assess the clinical outcomes of TTFields.

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Title: Tumor-treating fields as a fourth treating modality for glioblastoma: a meta-analysis
Authors: Dimitrios E. Magouliotis
Eftihia K. Asprodini
Konstantina A. Svokos
Vasiliki S. Tasiopoulou
Alexis A. Svokos
Steven A. Toms
Publication date: 01-06-2018
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 6/2018
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-018-3536-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Tumor-treating fields as a fourth treating modality for glioblastoma: a meta-analysis

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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