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01-05-2018 | Case Report - Brain Tumors

Intraventricular urokinase to treat a blocked ventriculoperitoneal shunt in a glioblastoma patient with leptomeningeal spread

Authors: Peter Y. M. Woo, James T. F. Zhuang, Jason M. K. Ho, Andrew Seto, Hoi-Tung Wong, Kwong-Yau Chan

Published in: Acta Neurochirurgica | Issue 5/2018

Abstract

Leptomeningeal spread and hydrocephalus are increasingly recognized as late disease complications of glioblastoma with almost a quarter of patients requiring early cerebrospinal fluid shunting. The neurosurgeon is challenged with maintaining shunt patency when tumor disease progression is rapid and adjuvant oncologic therapy has yet to be initiated. We describe our experience in treating a young female with diffuse glioblastoma leptomeningeal spread and communicating hydrocephalus who had several episodes of shunt obstruction due to intraluminal tumor cell-fibrin deposits. Regular intraventricular instillations of urokinase fibrinolytic therapy not only re-established shunt patency but also contributed to the resolution of her hydrocephalus.

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Title: Intraventricular urokinase to treat a blocked ventriculoperitoneal shunt in a glioblastoma patient with leptomeningeal spread
Authors: Peter Y. M. Woo
James T. F. Zhuang
Jason M. K. Ho
Andrew Seto
Hoi-Tung Wong
Kwong-Yau Chan
Publication date: 01-05-2018
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 5/2018
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-018-3509-9

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Intraventricular urokinase to treat a blocked ventriculoperitoneal shunt in a glioblastoma patient with leptomeningeal spread

Abstract

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