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Published in: Acta Neurochirurgica 9/2017

01-09-2017 | Original Article - Functional

Delayed complications of deep brain stimulation: 16-year experience in 249 patients

Authors: Gustavo Fernández-Pajarín, A. Sesar, B. Ares, J. L. Relova, E. Arán, M. Gelabert-González, A. Castro

Published in: Acta Neurochirurgica | Issue 9/2017

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Abstract

Background

Over the years, most of the deep brain stimulation (DBS) complications described have been mainly related to the surgery itself or the stimulation. Only a few authors have dealt with chronic complications or complications due to implanted material.

Methods

We retrospectively analyzed complications beyond the 1st month after surgery in 249 patients undergoing DBS at our site for 16 years, with 321 interventions overall.

Results

Our results show that infection is the most frequent delayed complication (12.5%), the pulse generator being the most common location. Lead breaks (9.3%) are the second most frequent complication. Symptomatic peri-lead edema and cyst formation were exceptional.

Conclusions

The best knowledge about DBS complications allows for better solutions. In case of infection, conservative treatment or partial removal of the DBS system appears to be safe and reasonable. Intracranial complications related to DBS material such as peri-lead edema and cyst formation have a good prognosis. They may appear long after DBS implantation.
Literature
1.
go back to reference Benabid AL, Chabardes S, Mitrofanis J, Pollak P (2009) Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson’s disease. Lancet Neurol 8:67e81CrossRef Benabid AL, Chabardes S, Mitrofanis J, Pollak P (2009) Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson’s disease. Lancet Neurol 8:67e81CrossRef
2.
go back to reference Boviatsis EJ, Stavrinou LC, Themistocleous M, Kouyialis AT, Sakas DE (2010) Surgical and hardware complications of deep brain stimulation. A seven-year experience and review of the literature. Acta Neurochir 152:2053–3062CrossRefPubMed Boviatsis EJ, Stavrinou LC, Themistocleous M, Kouyialis AT, Sakas DE (2010) Surgical and hardware complications of deep brain stimulation. A seven-year experience and review of the literature. Acta Neurochir 152:2053–3062CrossRefPubMed
3.
go back to reference Castro Bouzas D, Serramito García R, Relova Quinteiro JL, Castro García A, Ares Pensado B, Sesar Ignacio A, Gelabert-Gonzalez M (2013) Bowstringing as a complication of deep brain stimulation. Neurocirugia (Astur) 24(1):37–40CrossRef Castro Bouzas D, Serramito García R, Relova Quinteiro JL, Castro García A, Ares Pensado B, Sesar Ignacio A, Gelabert-Gonzalez M (2013) Bowstringing as a complication of deep brain stimulation. Neurocirugia (Astur) 24(1):37–40CrossRef
4.
go back to reference Deogaonkar M, Nazzaro JM, Machado A, Rezai A (2011) Transient, symptomatic, post-operative, non-infectious hypodensity around the deep brain stimulation (DBS) electrode. J Clin Neurosci 18(7):910–915CrossRefPubMed Deogaonkar M, Nazzaro JM, Machado A, Rezai A (2011) Transient, symptomatic, post-operative, non-infectious hypodensity around the deep brain stimulation (DBS) electrode. J Clin Neurosci 18(7):910–915CrossRefPubMed
5.
go back to reference Doshi PK (2011) Long-term surgical and hardware-related complications of deep brain stimulation. Stereotact Funct Neurosurg 89(2):89–95CrossRefPubMed Doshi PK (2011) Long-term surgical and hardware-related complications of deep brain stimulation. Stereotact Funct Neurosurg 89(2):89–95CrossRefPubMed
6.
go back to reference Englot DJ, Glastonbury CM, Larson PS (2011) Abnormal T2-weighted MRI signal surrounding leads in a subset of deep brain stimulation patients. Stereotact Funct Neurosurg 89(5):311–317CrossRefPubMed Englot DJ, Glastonbury CM, Larson PS (2011) Abnormal T2-weighted MRI signal surrounding leads in a subset of deep brain stimulation patients. Stereotact Funct Neurosurg 89(5):311–317CrossRefPubMed
7.
go back to reference Fenoy AJ, Simpson RK (2012) Management of device-related wound complications in deep brain stimulation surgery. J Neurosurg 116:1324–1332CrossRefPubMed Fenoy AJ, Simpson RK (2012) Management of device-related wound complications in deep brain stimulation surgery. J Neurosurg 116:1324–1332CrossRefPubMed
8.
go back to reference Follett KA, Weaver FM, Stern M, Hur K, Harris CL, Luo P, Marks WJ Jr, Rothlind J, Sagher O, Moy C, Pahwa R, Burchiel K, Hogarth P, Lai EC, Duda JE, Holloway K, Samii A, Horn S, Bronstein JM, Stoner G, Starr PA, Simpson R, Baltuch G, De Salles A, Huang GD, Reda DJ (2010) Pallidal versus Subthalamic deep-brain stimulation for Parkinson’s disease. N Engl J Med 362:2077–2091CrossRefPubMed Follett KA, Weaver FM, Stern M, Hur K, Harris CL, Luo P, Marks WJ Jr, Rothlind J, Sagher O, Moy C, Pahwa R, Burchiel K, Hogarth P, Lai EC, Duda JE, Holloway K, Samii A, Horn S, Bronstein JM, Stoner G, Starr PA, Simpson R, Baltuch G, De Salles A, Huang GD, Reda DJ (2010) Pallidal versus Subthalamic deep-brain stimulation for Parkinson’s disease. N Engl J Med 362:2077–2091CrossRefPubMed
9.
go back to reference Geissinger G, Neal JH (2007) Spontaneous twiddler’s syndrome in a patient with a deep brain stimulator. Surg Neurol 68:454–456CrossRefPubMed Geissinger G, Neal JH (2007) Spontaneous twiddler’s syndrome in a patient with a deep brain stimulator. Surg Neurol 68:454–456CrossRefPubMed
10.
go back to reference Jagid J, Madhavan K, Bregy A, Desai M, Ruiz A, Quencer R, Landy HJ (2015) Deep brain stimulation complicated by bilateral cystic cavitation around the leads in a patient with Parkinson’s disease. BMJ Case Rep. doi:10.1136/bcr-2015-211470 Jagid J, Madhavan K, Bregy A, Desai M, Ruiz A, Quencer R, Landy HJ (2015) Deep brain stimulation complicated by bilateral cystic cavitation around the leads in a patient with Parkinson’s disease. BMJ Case Rep. doi:10.​1136/​bcr-2015-211470
11.
12.
go back to reference Janson C, Maxwell R, Gupte AA, Abosch A (2010) Bowstringing as a complication of deep brain stimulation: case report. Neurosurgery 66(6):E1205CrossRefPubMed Janson C, Maxwell R, Gupte AA, Abosch A (2010) Bowstringing as a complication of deep brain stimulation: case report. Neurosurgery 66(6):E1205CrossRefPubMed
13.
go back to reference Ramirez-Zamora A, Levine D, Sommer DB, Dalfino J, Novak P, Pilitsis JG (2013) Intraparenchymal cyst development after deep brain stimulator placement. Stereotact Funct Neurosurg 91(5):338–341CrossRefPubMed Ramirez-Zamora A, Levine D, Sommer DB, Dalfino J, Novak P, Pilitsis JG (2013) Intraparenchymal cyst development after deep brain stimulator placement. Stereotact Funct Neurosurg 91(5):338–341CrossRefPubMed
14.
go back to reference Tong F, Ramirez-Zamora A, Gee L, Pilitsis J (2015) Unusual complications of deep brain stimulation. Neurosurg Rev 38(2):245–252CrossRefPubMed Tong F, Ramirez-Zamora A, Gee L, Pilitsis J (2015) Unusual complications of deep brain stimulation. Neurosurg Rev 38(2):245–252CrossRefPubMed
Metadata
Title
Delayed complications of deep brain stimulation: 16-year experience in 249 patients
Authors
Gustavo Fernández-Pajarín
A. Sesar
B. Ares
J. L. Relova
E. Arán
M. Gelabert-González
A. Castro
Publication date
01-09-2017
Publisher
Springer Vienna
Published in
Acta Neurochirurgica / Issue 9/2017
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-017-3252-7

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