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Acta Neurochirurgica
Published in: Acta Neurochirurgica 10/2016

01-10-2016 | Review Article - Brain Tumors

Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas

Authors: Ruichong Ma, Colin Watts

Published in: Acta Neurochirurgica | Issue 10/2016

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Abstract

Malignant gliomas are locally invasive tumors that offer a poor prognosis. Evidence shows that complete resection of the tumor at the time of surgery confers a significant improvement in overall survival. In recent years, 5- aminolevulinic acid (ALA)-induced fluorescence has been used by neurosurgeons to good effect in increasing the rate of complete resection. Despite the considerable interest in the use of 5-ALA in fluorescence-guided neurosurgery, the mechanisms behind the accumulation of Protoporphyrin IX (PpIX) in neoplastic tissue are unclear. In this review, we summarize the evidence in the literature on the mechanisms underlying the selective production of PpIX with a specific focus on gliomas.
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Metadata
Title
Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas
Authors
Ruichong Ma
Colin Watts
Publication date
01-10-2016
Publisher
Springer Vienna
Published in
Acta Neurochirurgica / Issue 10/2016
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-016-2897-y

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