Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Acta Neurochirurgica
Published in: Acta Neurochirurgica 9/2016

01-09-2016 | Case Report - Brain Tumors

Radiosurgery for infundibulum adenoma: stalk dose implications

Authors: Jennifer D. Sokolowski, Or Cohen-Inbar, Jason P. Sheehan

Published in: Acta Neurochirurgica | Issue 9/2016

Login to get access

Abstract

Treating pituitary adenomas in the infundibulum with stereotactic radiosurgery (SRS), achieving tumor volume control while preserving pituitary endocrine function and visual function, is challenging. We present a case of a recurrent remnant infundibular lesion treated with Gamma Knife surgery (GKS). The mass was treated with microsurgical resection twice, and the residual stalk lesion was treated with single-session SRS employing a margin dose of 15 Gy to the infundibulum. Five years after GKS, tumor regression persists without visual dysfunction or hypopituitarism. Radiosurgical doses of 30 Gy to the pituitary stalk may be tolerated by patients while maintaining endocrine function.
Literature
1.
Feigl GC, Bonelli CM, Berghold A, Mokry M (2002) Effects of Gamma Knife radiosurgery of pituitary adenomas on pituitary function. J Neurosurg 97(5 Suppl):415–421PubMed
2.
Feigl GC, Pistracher K, Berghold A, Mokry M (2010) Pituitary insufficiency as a side effect after radiosurgery for pituitary adenomas: the role of the hypothalamus. J Neurosurg 113(Suppl):153–159PubMed
3.
Jagannathan J, Yen CP, Pouratian N, Laws ER, Sheehan JP (2009) Stereotactic radiosurgery for pituitary adenomas: a comprehensive review of indications, techniques and long-term results using the Gamma Knife. J Neurooncol 92(3):345–356CrossRefPubMed
4.
Marek J, Jezkova J, Hana V, Krsek M, Bandurova L, Pecen L, Vladyka V, Liscak R (2011) Is it possible to avoid hypopituitarism after irradiation of pituitary adenomas by the Leksell Gamma Knife? Eur J Endocrinol 164(2):169–178CrossRefPubMed
5.
Pamir MN, Kilic T, Belirgen M, Abacioglu U, Karabekiroglu N (2007) Pituitary ade1nomas treated with Gamma Knife radiosurgery: volumetric analysis of 100 cases with minimum 3 year follow-up. Neurosurgery 61(2):270–280CrossRefPubMed
6.
Picozzi P, Losa M, Mortini P, Valle MA, Franzin A, Attuati L, Ferrari da Passano C, Giovanelli M (2005) Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas. J Neurosurg 102(Suppl):71–74CrossRefPubMed
7.
Sheehan JP, Starke RM, Mathieu D, Young B, Sneed PK, Chiang VL, Lee JY, Kano H, Park KJ, Niranjan A, Kondziolka D, Barnett GH, Rush S, Golfinos JG, Lunsford LD (2013) Gamma Knife radiosurgery for the management of nonfunctioning pituitary adenomas: a multicenter study. J Neurosurg 119(2):446–456CrossRefPubMed
8.
Sicignano G, Losa M, del Vecchio A, Cattaneo GM, Picozzi P, Bolognesi A, Mortini P, Calandrino R (2012) Dosimetric factors associated with pituitary function after Gamma Knife surgery (GKS) of pituitary adenomas. Radiother Oncol 104(1):119–124CrossRefPubMed
9.
Starke RM, Williams BJ, Jane JA Jr, Sheehan JP (2012) Gamma Knife surgery for patients with nonfunctioning pituitary macroadenomas: predictors of tumor control, neurological deficits, and hypopituitarism. J Neurosurg 117(1):129–135CrossRefPubMed
10.
Taussky P, Kalra R, Coppens J, Mohebali J, Jensen R, Couldwell WT (2011) Endocrinological outcome after pituitary transposition (hypophysopexy) and adjuvant radiotherapy for tumors involving the cavernous sinus. J Neurosurg 115(1):55–62CrossRefPubMed
11.
Vladyka V, Liscak R, Novotny J Jr, Marek J, Jezkova J (2003) Radiation tolerance of functioning pituitary tissue in Gamma Knife surgery for pituitary adenomas. Neurosurgery 52(2):309–316CrossRefPubMed
Metadata
Title
Radiosurgery for infundibulum adenoma: stalk dose implications
Authors
Jennifer D. Sokolowski
Or Cohen-Inbar
Jason P. Sheehan
Publication date
01-09-2016
Publisher
Springer Vienna
Published in
Acta Neurochirurgica / Issue 9/2016
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-016-2894-1

Other articles of this Issue 9/2016

Acta Neurochirurgica 9/2016 Go to the issue

Technical Note - Functional

Pushing the limits of the Leksell stereotactic frame for spinal lesions up to C3: fixation at the maxilla

Case Report - Vascular

Posterior atlantoaxial fusion as treatment option for extracranial vertebral artery dissecting aneurysm: a case report and literature review

Clinical Article - Spine

The role of ICP monitoring in patients with persistent cerebrospinal fluid leak following spinal surgery: a case series

Experimental Research - Functional

Subcutaneous trigeminal nerve field stimulation for refractory trigeminal pain: a cohort analysis

Clinical Article - Functional

Long-term clinical outcomes of spinal accessory nerve transfer to the suprascapular nerve in patients with brachial plexus palsy

Experimental Research - Brain Injury

Pentoxifylline Alleviates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage