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Acta Neurochirurgica
Published in: Acta Neurochirurgica 12/2014

01-12-2014 | Clinical Article - Brain Tumors

Predictive value of diffusion-weighted MRI for tumor consistency and resection rate of nonfunctional pituitary macroadenomas

Authors: Maysam Alimohamadi, Reza Sanjari, Abolghassem Mortazavi, Mohamad Shirani, Hedieh Moradi Tabriz, Homayoun Hadizadeh Kharazi, Abbas Amirjamshidi

Published in: Acta Neurochirurgica | Issue 12/2014

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Abstract

Backgrounds

Firm tumor consistency is one of the most important factors that impede sufficient removal of pituitary macroademoas via a transsphenoidal approach. The utility of diffusion-weighted (DW) magnetic resonance imaging (MRI) in predicting the tumor consistency and successfulness of transsphenoidal resection was evaluated in this study.

Methods

Thirty consecutive primary cases of nonfunctional pituitary macroadenomas were prospectively enrolled. Conventional and DW MRI were done for all the patients and the apparent diffusion coefficient (ADC) values and the signal intensity of the solid tumor were determined. Intraoperative report of tumor consistency, the degree of fibrosis and percentage of collagen content were documented. The 8 weeks postoperative MRI was used for calculation of the tumor resection rate.

Results

The tumor consistency was soft in 10 patients (33.3 %), intermediate in 14 patients (46.7 %) and hard in 6 patients (20 %). The mean collagen content percentage was 10, 23.5 and 66 % (p = 0.009) and the average resection rate was 75, 43 39 % in the three groups respectively (p = 0.001). The mean ADC value was not significantly correlated with the tumor consistency and resection rate. Tumors with isointense to hyperintense signal on DW MRI were more commonly removable by suction and had higher resection rates than those with hypointense signals (p = 0.019). For ADC values within the range of 600–740 × 10-3 mm2/s, a residual volume larger than 20 % of the tumor was more likely.

Conclusions

DW MRI was useful to predict the tumor consistency, collagen content and the chance of removal of pituitary macroadenomas through endoscopic transsphenoidal surgery, and is recommended in the preoperative patient evaluation.
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Metadata
Title
Predictive value of diffusion-weighted MRI for tumor consistency and resection rate of nonfunctional pituitary macroadenomas
Authors
Maysam Alimohamadi
Reza Sanjari
Abolghassem Mortazavi
Mohamad Shirani
Hedieh Moradi Tabriz
Homayoun Hadizadeh Kharazi
Abbas Amirjamshidi
Publication date
01-12-2014
Publisher
Springer Vienna
Published in
Acta Neurochirurgica / Issue 12/2014
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-014-2259-6

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