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Acta Neurochirurgica

Published in:

01-02-2012 | Clinical Article

Salvage treatment of distant recurrent brain metastases with Gamma Knife surgery

Authors: Patrick Hanssens, Bengt Karlsson, Ravindran Vashu, Tseng Tsai Yeo, Guus Beute

Published in: Acta Neurochirurgica | Issue 2/2012

Abstract

Background

The aim of the study was to analyze the results following salvage Gamma Knife® surgery (GKS) for distant recurrent brain metastases in patients previously treated with GKS for brain metastases.

Methods

Survival time and freedom from new distant recurrences (DR) were studied in 251 patients treated with salvage GKS for brain metastases that had developed following a first GKS. The patients were followed prospectively and the results related to a number of patient parameters as well as the results following the first GKS.

Results

The median survival time was 9.6 months, and the median time of freedom from developing DR was 7.5 months after salvage GKS. The survival time was unrelated to age, gender, prior WBRT, and primary disease. It was significantly longer in patients with a single DR at salvage GKS as compared to those with multiple ones (16 versus 8.3 months). Patients with 2–4 DRs lived longer than those with >4 lesions, 10 versus 5.8 months.

The survival was significantly longer following salvage GKS as compared to following the first GKS. The prognosis of a patient with DR may therefore be less ominous than previously assumed. A classification system for DRs based on their clinical impact and treatability is therefore suggested.

Conclusions

The longer survival time following salvage GKS as compared to following the first GKS suggests that many patients benefit from salvage GKS. A classification system of DR is suggested to estimate its clinical impact.

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Title: Salvage treatment of distant recurrent brain metastases with Gamma Knife surgery
Authors: Patrick Hanssens
Bengt Karlsson
Ravindran Vashu
Tseng Tsai Yeo
Guus Beute
Publication date: 01-02-2012
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 2/2012
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-011-1240-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Salvage treatment of distant recurrent brain metastases with Gamma Knife surgery

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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