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01-01-2012 | Clinical Article

Chemokines as markers of local inflammation and angiogenesis in patients with chronic subdural hematoma: a prospective study

Authors: Milo Stanisic, Staale Petter Lyngstadaas, Are Hugo Pripp, Ansgar Oddne Aasen, Karl-Fredrik Lindegaard, Jugoslav Ivanovic, Eivind Ilstad, Ane Konglund, Tiril Sandell, Omar Ellingsen, Terje Sæhle

Published in: Acta Neurochirurgica | Issue 1/2012

Abstract

Objective

The goal of this study was to investigate the chemokines CCL2, CXCL8, CXCL9 and CXCL10 as markers of the inflammatory responses in chronic subdural hematoma (CSDH).

Methods

Samples of peripheral venous blood and CSDH fluid (obtained during surgery) in 76 adult patients were prospectively analyzed. Chemokine values were assessed by a Multiplex antibody bead kit.

Results

We found significantly higher levels of chemokines CCL2, CXCL8, CXCL9 and CXCL10 in hematoma fluid compared with serum.

Conclusions

Chemokines are elevated in the hematoma cavity of patients with CSDH. It is likely that these signaling modulators play an important role in promoting local inflammation. Furthermore, biological activity of CCL2 and CXCL8 may promote neovascularization within the outer CSDH membrane, and a compensatory angiostatic activity of CXCL9 and CXCL10 may contribute to repairing this disorder. This phenomenon was restricted to the hematoma site, and the systemic chemokine levels might not reflect local immune responses.

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Title: Chemokines as markers of local inflammation and angiogenesis in patients with chronic subdural hematoma: a prospective study
Authors: Milo Stanisic
Staale Petter Lyngstadaas
Are Hugo Pripp
Ansgar Oddne Aasen
Karl-Fredrik Lindegaard
Jugoslav Ivanovic
Eivind Ilstad
Ane Konglund
Tiril Sandell
Omar Ellingsen
Terje Sæhle
Publication date: 01-01-2012
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 1/2012
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-011-1203-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Chemokines as markers of local inflammation and angiogenesis in patients with chronic subdural hematoma: a prospective study

Abstract

Objective

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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