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Acta Neurochirurgica

Published in:

01-02-2010 | Experimental Research

Expression of extracellular matrix-proteins in perisellar connective tissue and dura mater

Authors: Ulrich J. Knappe, Thomas Fink, Annette Fisseler-Eckhoff, Robert Schoenmayr

Published in: Acta Neurochirurgica | Issue 2/2010

Abstract

Purpose

To describe the pattern of expression of extracellular matrix (ECM) proteins in perisellar connective tissue.

Methods

Dural and perisellar specimens from ten individuals were investigated immunohistochemically for collagens I to IV, tenascin, fibronectin, elastin, laminin, and vitronectin.

Findings

Collagen I and III and fibronectin were strongly expressed and collagen IV, tenascin, and vitronectin were moderately expressed in the boundaries of the sella and around the CS. In six of nine specimens from the anterior boundary of the sella, and in 11 of 19 samples from the lateral boundary of the sella (medial wall of CS), two different layers could be detected by the expression of different ECM proteins. None of the antigens generally allowed differentiation between two layers of the pituitary envelope.

Conclusions

The pituitary boundary may consist of a single or a double layer, infrequently differentiated from each other by the expression of different ECM proteins.

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Title: Expression of extracellular matrix-proteins in perisellar connective tissue and dura mater
Authors: Ulrich J. Knappe
Thomas Fink
Annette Fisseler-Eckhoff
Robert Schoenmayr
Publication date: 01-02-2010
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 2/2010
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-009-0497-9

At a glance: The STEP trials

Springer Medicine

Expression of extracellular matrix-proteins in perisellar connective tissue and dura mater

Abstract

Purpose

Methods

Findings

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Findings

Conclusions

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