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01-11-2009 | Clinical Article

Long-term outcome and survival of surgically treated supratentorial low-grade glioma in adult patients

Authors: Ahmadi Rezvan, Dictus Christine, Hartmann Christian, Zürn Olga, Edler Lutz, Hartmann Marius, Combs Stephanie, Herold-Mende Christel, Wirtz Christian Rainer, Unterberg Andreas

Published in: Acta Neurochirurgica | Issue 11/2009

Abstract

Purpose

The appropriate management of low-grade gliomas is still a matter of debate. So far, there are no randomized studies that analyze the impact of surgical resection on patient outcome. The value of the data obtained from the few retrospective reports available is often limited.

Patients and methods

In the present study, we performed an analysis on data of 130 adult low-grade glioma patients. Extent of the resection was evaluated in correlation to the overall survival (OS) and progression-free survival (PFS) using Cox regression multivariate analysis.

Results

Extended surgery was shown to prolong OS and PFS significantly. Re-surgery in the case of a tumor relapse has a significant impact on OS and PFS, too.

Conclusions

In summary, we could retrospectively evaluate a large case series of well-defined low-grade gliomas patients with a long follow-up period showing that extended surgery would be the most effective therapy for low-grade glioma patients even in recurrent diseases.

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Title: Long-term outcome and survival of surgically treated supratentorial low-grade glioma in adult patients
Authors: Ahmadi Rezvan
Dictus Christine
Hartmann Christian
Zürn Olga
Edler Lutz
Hartmann Marius
Combs Stephanie
Herold-Mende Christel
Wirtz Christian Rainer
Unterberg Andreas
Publication date: 01-11-2009
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 11/2009
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-009-0435-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Long-term outcome and survival of surgically treated supratentorial low-grade glioma in adult patients

Abstract

Purpose

Patients and methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Patients and methods

Results

Conclusions

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