Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Acta Neurochirurgica
Published in: Acta Neurochirurgica 11/2009

01-11-2009 | Clinical Article

Significance of serial S100b and NSE serum measurements in surgically treated patients with spondylotic cervical myelopathy

Authors: G. Marquardt, M. Setzer, A. Szelenyi, V. Seifert, R. Gerlach

Published in: Acta Neurochirurgica | Issue 11/2009

Login to get access

Abstract

Background

Predicting functional outcome following surgery performed for spinal cord compression is still a considerable problem. Recent observations, though, strongly suggest that with serial measurements of serum S100b, this might be possible in patients with subacute spinal cord compression. The aim of this study was to examine whether this potential significance of S100b applies as well to patients with spondylotic cervical myelopathy. A further purpose was to assess the value of NSE in this regard, another biochemical marker widely used to monitor cerebral lesions.

Methods

Fifty-one patients were included in this prospective study. Outcome was considered as favourable in case of neurological improvement with preservation or retrieval of walking ability, whereas non-improvement without restoration of gait function was regarded as unfavourable. The preoperative levels of S100b and NSE were correlated with the degree of paresis, duration of symptoms, and presence of intramedullary high signal intensities on MRI. The postoperative values of both markers were correlated with outcome.

Findings

The preoperative levels of S100b were neither correlated with degree or duration of paresis nor with outcome. In case of an uncomplicated course the postoperative levels of S100b were also not correlated with outcome. In complicated courses with acute postoperative deterioration normal values on the 3rd day after the event were associated with a favourable outcome, whereas one patient with unfavourable outcome showed a persistent pathological increase. The serum levels of NSE were not correlated with clinical parameters or with outcome in any of the cases.

Conclusions

Serial S100b serum measurements do not permit prediction of functional outcome in patients with spondylotic cervical myelopathy in case of an uncomplicated postoperative course. In complicated courses with postoperative deterioration, such measurements reflect postoperative events with possibly prognostic relevance. NSE does not have any significance in these patients with chronic lesions of the spinal cord.
Literature
1.
Arnasson O, Carlsson CA, Pellettieri L (1987) Surgical and conservative treatment of cervical spondylotic radiculopathy and myelopathy. Acta Neurochir (Wien) 84:48–53CrossRef
2.
Bertalanffy H, Eggert HR (1988) Clinical long-term results of anterior discectomy without fusion for treatment of cervical radiculopathy and myelopathy. A follow-up of 164 cases. Acta Neurochir (Wien) 90:127–135CrossRef
3.
Chung SS, Lee CS, Chung KH (2002) Factors affecting the surgical results of expansive laminoplasty for cervical spondylotic myelopathy. Int Orthop 26:334–338CrossRefPubMed
4.
Ebersold MJ, Pare MC, Quast LM (1995) Surgical treatment for cervical spondylitic myelopathy. J Neurosurg 82:745–751CrossRefPubMed
5.
Emery SE, Bohlman HH, Bolesta MJ, Jones PK (1998) Anterior cervical decompression and arthrodesis for the treatment of cervical spondylotic myelopathy. Two to seventeen-year follow-up. J Bone Joint Surg Am 80:941–951
6.
Kohno K, Kumon Y, Oka Y, Matsui S, Ohue S, Sakaki S (1997) Evaluation of prognostic factors following expansive laminoplasty for cervical spinal stenotic myelopathy. Surg Neurol 48:237–245CrossRefPubMed
7.
Kumar VG, Rea GL, Mervis LJ, McGregor JM (1999) Cervical spondylotic myelopathy: functional and radiographic long-term outcome after laminectomy and posterior fusion. Neurosurgery 44:771–777CrossRefPubMed
8.
Marquardt G, Setzer M, Seifert V (2004) Protein S-100b as serum marker for prediction of functional outcome in metastatic spinal cord compression. Acta Neurochir (Wien) 146:449–452CrossRef
9.
Marquardt G, Setzer M, Seifert V (2004) Protein S-100b for individual prediction of functional outcome in spinal epidural empyema. Spine 29:59–62CrossRefPubMed
10.
Mehalic TF, Pezzuti RT, Applebaum BI (1990) Magnetic resonance imaging and cervical spondylotic myelopathy. Neurosurgery 26:217–226CrossRefPubMed
11.
Morio Y, Yamamoto K, Kuranobu K, Murata M, Tuda K (1994) Does increased signal intensity of the spinal cord on MR images due to cervical myelopathy predict prognosis? Arch Orthop Trauma Surg 113:254–259CrossRefPubMed
12.
Naderi S, Ozgen S, Pamir MN, Ozek MM, Erzen C (1998) Cervical spondylotic myelopathy: surgical results and factors affecting prognosis. Neurosurgery 43:43–49CrossRefPubMed
13.
Saunders RL, Bernini PM, Shirreffs TG Jr, Reeves AG (1991) Central corpectomy for cervical spondylotic myelopathy: a consecutive series with long-term follow-up evaluation. J Neurosurg 74:163–170CrossRefPubMed
14.
Yamazaki T, Yanaka K, Sato H, Uemura K, Tsukada A, Nose T (2003) Cervical spondylotic myelopathy: surgical results and factors affecting outcome with special reference to age differences. Neurosurgery 52:122–126CrossRefPubMed
15.
Yone K, Sakou T, Yanase M, Ijiri K (1992) Preoperative and postoperative magnetic resonance image evaluations of the spinal cord in cervical myelopathy. Spine 17(10 Suppl):388–392CrossRef
Metadata
Title
Significance of serial S100b and NSE serum measurements in surgically treated patients with spondylotic cervical myelopathy
Authors
G. Marquardt
M. Setzer
A. Szelenyi
V. Seifert
R. Gerlach
Publication date
01-11-2009
Publisher
Springer Vienna
Published in
Acta Neurochirurgica / Issue 11/2009
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-009-0408-0

Other articles of this Issue 11/2009

Acta Neurochirurgica 11/2009 Go to the issue

Erratum

Transforaminal percutaneous endoscopic lumbar discectomy for upper lumbar disc herniation: clinical outcome, prognostic factors, and technical consideration

Case Report

Disseminated intravascular coagulation after isolated mild head injury

Neurosurgical Techniques

Simple identification of the third segment of the extracranial vertebral artery by extreme lateral inferior transcondylar-transtubercular exposure (ELITE)

Clinical Article

Long-term survivors of glioblastoma: clinical features and molecular analysis

Neurosurgical Techniques

Cylindrical channel retractor for intraventricular tumour surgery—a simple and inexpensive device

Clinical Article

Long-term outcome and survival of surgically treated supratentorial low-grade glioma in adult patients