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Acta Neurochirurgica

Published in:

01-10-2009 | Clinical Article

Atypical speech activations: PET results of 92 patients with left-hemispheric epilepsy

Authors: Taner Tanriverdi, Denise Klein, Kelvin Mok, Sylvain Milot, Jasem Al-Hashel, Nicole Poulin, Andre Olivier

Published in: Acta Neurochirurgica | Issue 10/2009

Abstract

Purpose

Language lateralization and factors that may influence language lateralization were investigated using positron emission tomography.

Methods

Ninety-two right-handed patients who had left-sided lesions (tumors, focal cortical dysplasia, and vascular lesions) and 19 right-handed normal subjects were included and synonym generation task was used for evaluation of language lateralization.

Results

As expected, the majority of individuals in both groups showed left hemisphere dominance. Lesions in the vicinity of language-related areas did not alter patterns of activation responses. However, atypical inferior frontal gyrus (IFG) activations (33.6%) were more commonly observed in the patient group than in the control group (21%). There were no clear right-sided IFG activations in the control group but almost 28% of the patients showed clear right-sided IFG activations. Atypical language lateralization was strongly correlated with duration of seizure (p = 0.01) and early age at onset (p = 0.03).

Conclusions

Our data provide evidence for inter-hemispheric plasticity related to language function as a response to lesions involving the left hemisphere. A better understanding of the dynamic organization of the brain and about the interaction between the lesion and reactional plasticity will lead to changes in surgical strategy, which will enable us to perform a total removal of the lesion involving eloquent brain areas with improved functional outcome.

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Title: Atypical speech activations: PET results of 92 patients with left-hemispheric epilepsy
Authors: Taner Tanriverdi
Denise Klein
Kelvin Mok
Sylvain Milot
Jasem Al-Hashel
Nicole Poulin
Andre Olivier
Publication date: 01-10-2009
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 10/2009
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-009-0373-7

At a glance: The STEP trials

Springer Medicine

Atypical speech activations: PET results of 92 patients with left-hemispheric epilepsy

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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