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Acta Neurochirurgica

Published in:

01-05-2009 | Neurovascular Observations

Comparison of experimental aneurysms embolized with second-generation embolic devices and platinum coils

Authors: Monika Killer, Thomas Hauser, Andrea Wenger, Bernd Richling, Gunther Ladurner

Published in: Acta Neurochirurgica | Issue 5/2009

Abstract

Purpose

The purpose of the study was to compare the performance of second-generation embolic devices with that of platinum coils in experimental aneurysms.

Methods

Microsurgically constructed bifurcation aneurysms in rabbits were embolized with platinum coils (n = 7), HydroCoils 10 (n = 10), HydroSoft (n = 14) or Cerecyte (n = 6) devices. After 1 month, angiographic occlusion was scored and the aneurysms were histologically evaluated by light microscopy. Continuous and ordinal results were compared using ANOVA/Tukey–Kramer HSD and χ² tests respectively.

Results

Angiographic occlusion at follow-up was increased in the HydroCoil and HydroSoft groups and decreased in the platinum coil and Cerecyte groups. Fibrovascular tissue was observed in the sac of the Cerecyte group, while mixtures of fibrovascular tissue and fibrinous thrombus were observed in the other three groups. The inflammatory response and endothelialization of the neck were similar in all groups.

Conclusions

Expansile hydrogel devices have led to increased progressive occlusion, while degradable polymer devices led to an increased rate of thrombus organization compared with platinum coils.

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Title: Comparison of experimental aneurysms embolized with second-generation embolic devices and platinum coils
Authors: Monika Killer
Thomas Hauser
Andrea Wenger
Bernd Richling
Gunther Ladurner
Publication date: 01-05-2009
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 5/2009
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-009-0237-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Comparison of experimental aneurysms embolized with second-generation embolic devices and platinum coils

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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