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Acta Neurochirurgica

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01-05-2009 | Clinical Article

Re-operation is a safe and effective therapeutic strategy in recurrent WHO grade II gliomas within eloquent areas

Authors: Juan Martino, Luc Taillandier, Sylvie Moritz-Gasser, Peggy Gatignol, Hugues Duffau

Published in: Acta Neurochirurgica | Issue 5/2009

Abstract

Background

To analyze the functional and oncological results after re-operation for recurrent WHO grade II Glioma located in eloquent regions.

Method

We reviewed a consecutive series of 19 patients with GIIG within functional areas who underwent two operations separated by at least 1 year. Intraoperative electrical stimulation mapping was used in all operations for recurrence and in 14 of the initial procedures. A specific rehabilitation was provided.

Findings

At the first operation, we performed 14 subtotal and 5 partial resections. Eighteen patients returned to a normal socio-professional life. Nine patients received adjuvant treatment. At the second operation, we performed 1 total, 13 subtotal and 5 partial resections. Three patients with a preoperative neurological deficit improved, 13 remained unchanged, and 3 slight new deficits appeared. In 14 of the 17 patients with preoperative chronic epilepsy, the seizures were reduced or disappeared. Sixteen patients returned to a normal socio-professional life. Pathohistological examination showed that 11 tumours had progressed to high-grade glioma. The median time between the two operations was 4.1 years (range 1 to 7.8 years) and the median follow-up from initial diagnosis was 6.6 years (range 2.3 to 14.3 years). No deaths occurred during the follow-up period.

Conclusions

Repeat operations guided by intra-operative electrical stimulation is an efficacious treatment for recurrent grade II glioma in an eloquent area.

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Title: Re-operation is a safe and effective therapeutic strategy in recurrent WHO grade II gliomas within eloquent areas
Authors: Juan Martino
Luc Taillandier
Sylvie Moritz-Gasser
Peggy Gatignol
Hugues Duffau
Publication date: 01-05-2009
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 5/2009
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-009-0232-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Re-operation is a safe and effective therapeutic strategy in recurrent WHO grade II gliomas within eloquent areas

Abstract

Background

Method

Findings

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Method

Findings

Conclusions

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