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Surgery Today
Published in: Surgery Today 12/2020

01-12-2020 | Metastasis | Review Article

Clinical implications of cancer stem cells in digestive cancers: acquisition of stemness and prognostic impact

Authors: Ryouichi Tsunedomi, Kiyoshi Yoshimura, Nobuaki Suzuki, Shoichi Hazama, Hiroaki Nagano

Published in: Surgery Today | Issue 12/2020

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Abstract

Digestive system cancers are the most frequent cancers worldwide and often associated with poor prognosis because of their invasive and metastatic characteristics. Recent studies have found that the plasticity of cancer cells can impart cancer stem-like properties via the epithelial–mesenchymal transition (EMT). Cancer stem-like properties such as tumor initiation are integral to the formation of metastasis, which is the main cause of poor prognosis. Numerous markers of cancer stem cells (CSCs) have been identified in many types of cancer. Therefore, CSCs, via their stem cell-like functions, may play an important role in prognosis after surgery. While several reports have described prognostic analysis using CSC markers, few reviews have summarized CSCs and their association with prognosis. Herein, we review the prognostic potential of eight CSC markers, CD133, CD44, CD90, ALDH1A1, EPCAM, SOX2, SOX9, and LGR5, in digestive cancers including those of the pancreas, colon, liver, gastric, and esophagus.
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Metadata
Title
Clinical implications of cancer stem cells in digestive cancers: acquisition of stemness and prognostic impact
Authors
Ryouichi Tsunedomi
Kiyoshi Yoshimura
Nobuaki Suzuki
Shoichi Hazama
Hiroaki Nagano
Publication date
01-12-2020
Publisher
Springer Singapore
Keyword
Metastasis
Published in
Surgery Today / Issue 12/2020
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-020-01968-x

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