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01-01-2019 | Original Article

Prevalence of and risk factors for thyroid carcinoma in patients with familial adenomatous polyposis: results of a multicenter study in Japan and a systematic review

Authors: Haruki Sada, Takao Hinoi, Hideki Ueno, Tatsuro Yamaguchi, Yasuhiro Inoue, Tsuyoshi Konishi, Hirotoshi Kobayashi, Yukihide Kanemitsu, Fumio Ishida, Hideyuki Ishida, Naohiro Tomita, Nagahide Matsubara, Kenichi Sugihara

Published in: Surgery Today | Issue 1/2019

Abstract

Purpose

To investigate the recent Japanese prevalence of thyroid cancer and its characteristics in familial adenomatous polyposis (FAP) patients, through the development of surveillance programs.

Methods

The subjects of this study were 282 (93.1%) FAP patients for whom information on thyroid cancer was available, from among 303 patients registered in “the Retrospective Cohort Study of Familial Adenomatous Polyposis in Japan” database. We evaluated the prevalence and risk factors for thyroid cancer and integrated and/or compared our findings with those of previous reports, using a systematic review, including a meta-analysis.

Results

Thyroid cancer was diagnosed in 16 women (11.4%) and 2 men (1.4%), at 17–41 years and 39–57 years of age, respectively. The prevalence of thyroid cancer was 6.4%, with a female-to-male ratio of 8:1, which is comparable to reports from other countries. A young age of < 33 years at the FAP diagnosis and female gender were identified as independent risk factors for thyroid cancer.

Conclusions

FAP-associated thyroid cancer predominantly affects young women, both in Japan and other countries. Since FAP is generally diagnosed when patients are in their 20 s or older, regular screening for thyroid cancer is recommended for all FAP patients, but especially women, from their early 20 s.

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Title: Prevalence of and risk factors for thyroid carcinoma in patients with familial adenomatous polyposis: results of a multicenter study in Japan and a systematic review
Authors: Haruki Sada
Takao Hinoi
Hideki Ueno
Tatsuro Yamaguchi
Yasuhiro Inoue
Tsuyoshi Konishi
Hirotoshi Kobayashi
Yukihide Kanemitsu
Fumio Ishida
Hideyuki Ishida
Naohiro Tomita
Nagahide Matsubara
Kenichi Sugihara
Publication date: 01-01-2019
Publisher: Springer Singapore
Published in: Surgery Today / Issue 1/2019
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-018-1710-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Prevalence of and risk factors for thyroid carcinoma in patients with familial adenomatous polyposis: results of a multicenter study in Japan and a systematic review

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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