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Published in: Surgery Today 12/2018

01-12-2018 | Original Article

High intramuscular adipose tissue content as a precondition of sarcopenia in patients with aortic aneurysm

Authors: Yutaka Matsubara, Tadashi Furuyama, Ken Nakayama, Keiji Yoshiya, Kentaro Inoue, Koichi Morisaki, Masazumi Kume, Yoshihiko Maehara

Published in: Surgery Today | Issue 12/2018

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Abstract

Purpose

Sarcopenia is a major problem of the elderly. Although little is known about the cause of sarcopenia, the intramuscular adipose tissue content (IMAC) is known to be a cause of sarcopenia. The aim of this study was to investigate the significance of IMAC as a cause of sarcopenia.

Methods

We evaluated patients who underwent aneurysm repair and were monitored preoperatively and 3 years postoperatively by computed tomography (CT). The skeletal muscle area and IMAC were measured on preoperative L3 CT images. The clinical characteristics and risk factors for skeletal muscle wasting were assessed.

Results

Among the 155 patients, 38 (24.5%) had > 10% skeletal muscle wasting 3 years after the operation. Patients with > 10% skeletal muscle wasting had higher IMACs of the iliopsoas (− 0.31 ± 0.01 vs. −0.45 ± 0.01, P < 0.001) muscles and higher rates of cerebrovascular infarctions (7.7 vs. 23.7%, P = 0.0068), lung cancer (0 vs. 10.5%, P < 0.001), and urgent operations (0.9 vs. 10.5%, P = 0.029) and a longer postoperative fasting period (1.3 ± 0.1 vs. 3.1 ± 0.9 days, P < 0.001) than those without > 10% skeletal muscle wasting. The IMAC of the iliopsoas muscle correlated strongly with skeletal muscle wasting (P < 0.05, r = 0.70).

Conclusions

A high IMAC of the iliopsoas muscle may cause sarcopenia and thus be a clinical target in disease prevention.
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Metadata
Title
High intramuscular adipose tissue content as a precondition of sarcopenia in patients with aortic aneurysm
Authors
Yutaka Matsubara
Tadashi Furuyama
Ken Nakayama
Keiji Yoshiya
Kentaro Inoue
Koichi Morisaki
Masazumi Kume
Yoshihiko Maehara
Publication date
01-12-2018
Publisher
Springer Singapore
Published in
Surgery Today / Issue 12/2018
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-018-1697-9

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