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Surgery Today
Published in: Surgery Today 10/2018

01-10-2018 | Original Article

Single lung transplantation for lymphangioleiomyomatosis: a single-center experience in Japan

Authors: Hisashi Oishi, Tatsuaki Watanabe, Yasushi Matsuda, Masafumi Noda, Yutaka Ejima, Yoshikatsu Saiki, Kuniaki Seyama, Takashi Kondo, Yoshinori Okada

Published in: Surgery Today | Issue 10/2018

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Abstract

Purpose

Lung transplantation is accepted as an effective modality for patients with end-stage pulmonary lymphangioleiomyomatosis (LAM). Generally, bilateral lung transplantation is preferred to single lung transplantation (SLT) for LAM because of native lung-related complications, such as pneumothorax and chylothorax. It remains controversial whether SLT is a suitable surgical option for LAM. The objective of this study was to evaluate the morbidity, mortality and outcome after SLT for LAM in a lung transplant center in Japan.

Methods

We reviewed the records of 29 patients who underwent SLT for LAM in our hospital between March, 2000 and November, 2017. The data collected included the pre-transplant demographics of recipients, surgical characteristics, complications, morbidity, mortality and survival after SLT for LAM.

Results

The most common complication after SLT for LAM was contralateral pneumothorax (n = 7; 24.1%). Six of these recipients were treated successfully with chest-tube placement and none required surgery for the pneumothorax. The second-most common complication was chylous pleural effusion (n = 6; 20.7%) and these recipients were all successfully treated by pleurodesis. The 5-year survival rate after SLT for LAM was 79.5%.

Conclusion

LAM-related complications after SLT for this disease can be managed. SLT is a treatment option and may improve access to lung transplantation for patients with end-stage LAM.
Literature
1.
Kpodonu J, Massad MG, Chaer RA, Caines A, Evans A, Snow NJ, et al. The US experience with lung transplantation for pulmonary lymphangioleiomyomatosis. J Hear Lung Transpl. 2005;24:1247–53.CrossRef
2.
Benden C, Rea F, Behr J, Corris PA, Reynaud-Gaubert M, Stern M, et al. Lung transplantation for lymphangioleiomyomatosis: the European experience. J Hear lung Transpl. 2009;28:1–7.CrossRef
3.
Yusen RD, Edwards LB, Kucheryavaya AY, Benden C, Dipchand AI, Goldfarb SB, et al. The Registry of the International Society for Heart and Lung Transplantation: thirty-second Official Adult Lung and Heart-Lung Transplantation Report–2015; focus theme: early Graft Failure. J Hear Lung Transpl. 2015;34:1264–77.CrossRef
4.
Sato M, Okada Y, Oto T, Minami M, Shiraishi T, Nagayasu T, et al. Registry of the Japanese Society of Lung and Heart–Lung Transplantation: official Japanese lung transplantation report, 2014. Gen Thorac Cardiovasc Surg. 2014;62:594–601.CrossRefPubMed
5.
Pechet TT, Meyers BF, Guthrie TJ, Battafarano RJ, Trulock EP, Cooper JD, et al. Lung transplantation for lymphangioleiomyomatosis. J Heart Lung Transpl. 2004;23:301–8.CrossRef
6.
Boehler A, Speich R, Russi EW, Walter W. Lung transplantation for lymphangioleiomyomatosis. N Engl J Med. 1996;335:1275–80.CrossRefPubMed
7.
Reynaud-Gaubert M, Mornex J-F, Mal H, Treilhaud M, Dromer C, Quétant S, et al. Lung transplantation for lymphangioleiomyomatosis: the French experience. Transplantation. 2008;86:515–20.CrossRefPubMed
8.
Machuca TN, Losso MJ, Camargo SM, Schio SM, Melo IA, Hochhegger B, et al. Lung transplantation for lymphangioleiomyomatosis: single-center Brazilian experience with no chylothorax. Transpl Proc. 2011;43:236–8.CrossRef
9.
Ohara T, Oto T, Miyoshi K, Tao H, Yamane M, Toyooka S, et al. Sirolimus ameliorated post lung transplant chylothorax in lymphangioleiomyomatosis. Ann Thorac Surg. 2008;86:e7–8.CrossRef
10.
Harari S, Elia D, Torre O, Bulgheroni E, Provasi E, Moss J. Sirolimus therapy for patients with lymphangioleiomyomatosis leads to loss of chylous ascites and circulating LAM cells. Chest. 2016;150:e29–e32 (American College of Chest Physicians).CrossRefPubMedPubMedCentral
11.
Taveira-dasilva AM, Hathaway O, Stylianou M, Moss J. Changes in lung function and chylous effusions in patients with lymphangioleiomyomatosis treated with sirolimus. Ann Intern Med. 2011;154:797–805.CrossRefPubMedPubMedCentral
12.
Ando K, Kurihara M, Kataoka H, Ueyama M, Togo S, Sato T, et al. Efficacy and safety of low-dose sirolimus for treatment of lymphangioleiomyomatosis. Respir Investig. 2013;51:175–83.CrossRefPubMed
13.
14.
Ito T, Suno M, Sakamoto K, Yoshizaki Y, Yamamoto K, Nakanishi R, et al. Therapeutic effect of sirolimus for lymphangioleiomyomatosis remaining in the abdominopelvic region after lung transplantation: a case report. Transpl Proc. 2016;48:271–4.CrossRef
15.
King-Biggs MB, Dunitz JM, Park SJ, Kay Savik S, Hertz MI. Airway anastomotic dehiscence associated with use of sirolimus immediately after lung transplantation. Transplantation. 2003;75:1437–43.CrossRefPubMed
16.
Groetzner J, Kur F, Spelsberg F, Behr J, Frey L, Bittmann I, et al. Airway anastomosis complications in de novo lung transplantation with sirolimus-based immunosuppression. J Hear Lung Transpl. 2004;23:632–8.CrossRef
17.
Thabut G, Christie JD, Ravaud P, Castier Y, Brugière O, Fournier M, et al. Survival after bilateral versus single lung transplantation for patients with chronic obstructive pulmonary disease: a retrospective analysis of registry data. Lancet. 2008;371:744–51.CrossRefPubMed
18.
Munson JC, Christie JD, Halpern SD. The societal impact of single versus bilateral lung transplantation for chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2011;184:1282–8.CrossRefPubMedPubMedCentral
19.
Thabut G, Christie JD, Ravaud P, Castier Y. Annals of internal medicine article survival after bilateral versus single-lung transplantation for. Ann Intern Med. 2009;151:767–74.CrossRefPubMed
20.
Ando K, Okada Y, Akiba M, Kondo T, Kawamura T, Okumura M, et al. Lung transplantation for lymphangioleiomyomatosis in Japan. PLoS One. 2016;11:1–14.
Metadata
Title
Single lung transplantation for lymphangioleiomyomatosis: a single-center experience in Japan
Authors
Hisashi Oishi
Tatsuaki Watanabe
Yasushi Matsuda
Masafumi Noda
Yutaka Ejima
Yoshikatsu Saiki
Kuniaki Seyama
Takashi Kondo
Yoshinori Okada
Publication date
01-10-2018
Publisher
Springer Singapore
Published in
Surgery Today / Issue 10/2018
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-018-1678-z

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