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Published in: Surgery Today 7/2018

01-07-2018 | Original Article

Additional lymph node dissection for primary colorectal cancer invading another colon region

Authors: Ryuma Tokunaga, Yasuo Sakamoto, Shigeki Nakagawa, Yuji Miyamoto, Naoya Yoshida, Hideo Baba

Published in: Surgery Today | Issue 7/2018

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Abstract

Purpose

Surgery remains the curative treatment of choice for colorectal cancer (CRC). However, to our knowledge, no report has addressed the usefulness of additional regional lymph node dissection for primary CRC that has invaded another colon region.

Methods

We reviewed the clinicopathological characteristics and outcomes of eight patients who underwent surgery between March, 2005 and August, 2014, for CRC that invaded another region of the colon.

Results

Five patients underwent additional regional lymph node dissection in the area of the invaded colon and one patient had lymph node metastasis in the region. Two of three patients who did not undergo additional regional lymph node dissection were found to have regional lymph node recurrences in the area during the follow-up period. Although there was no statistical correlation between extra-regional lymph node metastasis and clinicopathological or operative factors, the patients with extra-regional lymph node metastasis or recurrence had primary regional lymph node metastasis.

Conclusion

For curative intent, surgeons may need to perform additional regional lymph node dissection for primary CRC invading another colon region.
Literature
2.
go back to reference Adam R, de Gramont A, Figueras J, Kokudo N, Kunstlinger F, Loyer E, et al. Managing synchronous liver metastases from colorectal cancer: a multidisciplinary international consensus. Cancer Treat Rev. 2015;41:729–41.CrossRefPubMed Adam R, de Gramont A, Figueras J, Kokudo N, Kunstlinger F, Loyer E, et al. Managing synchronous liver metastases from colorectal cancer: a multidisciplinary international consensus. Cancer Treat Rev. 2015;41:729–41.CrossRefPubMed
3.
go back to reference Booth CM, Nanji S, Wei X, Mackillop WJ. Outcomes of resected colorectal cancer lung metastases in routine clinical practice: a population-based study. Ann Surg Oncol. 2016;23:1057–63.CrossRefPubMed Booth CM, Nanji S, Wei X, Mackillop WJ. Outcomes of resected colorectal cancer lung metastases in routine clinical practice: a population-based study. Ann Surg Oncol. 2016;23:1057–63.CrossRefPubMed
4.
go back to reference Choi PW, Kim HC, Kim AY, Jung SH, Yu CS, Kim JC. Extensive lymphadenectomy in colorectal cancer with isolated para-aortic lymph node metastasis below the level of renal vessels. J Surg Oncol. 2010;101:66–71.CrossRefPubMed Choi PW, Kim HC, Kim AY, Jung SH, Yu CS, Kim JC. Extensive lymphadenectomy in colorectal cancer with isolated para-aortic lymph node metastasis below the level of renal vessels. J Surg Oncol. 2010;101:66–71.CrossRefPubMed
5.
go back to reference Nordlinger B, Sorbye H, Glimelius B, Poston GJ, Schlag PM, Rougier P, et al. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial. Lancet. 2008;371:1007–16.CrossRefPubMedPubMedCentral Nordlinger B, Sorbye H, Glimelius B, Poston GJ, Schlag PM, Rougier P, et al. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial. Lancet. 2008;371:1007–16.CrossRefPubMedPubMedCentral
6.
go back to reference Montesani C, Ribotta G, De Milito R, Pronio A, D’Amato A, Narilli P, et al. Extended resection in the treatment of colorectal cancer. Int J Colorectal Dis. 1991;6:161–4.CrossRefPubMed Montesani C, Ribotta G, De Milito R, Pronio A, D’Amato A, Narilli P, et al. Extended resection in the treatment of colorectal cancer. Int J Colorectal Dis. 1991;6:161–4.CrossRefPubMed
7.
go back to reference Winter DC, Walsh R, Lee G, Kiely D, O’Riordain MG, O’Sullivan GC. Local involvement of the urinary bladder in primary colorectal cancer: outcome with en bloc resection. Ann Surg Oncol. 2007;14:441–6.CrossRefPubMed Winter DC, Walsh R, Lee G, Kiely D, O’Riordain MG, O’Sullivan GC. Local involvement of the urinary bladder in primary colorectal cancer: outcome with en bloc resection. Ann Surg Oncol. 2007;14:441–6.CrossRefPubMed
8.
go back to reference The Japanese Society for Cancer of the Colon and Rectum. JSCCR guidelines 2005 for the treatment of colorectal cancer. Tokyo: Kanehara & Co., Ltd.; 2005. The Japanese Society for Cancer of the Colon and Rectum. JSCCR guidelines 2005 for the treatment of colorectal cancer. Tokyo: Kanehara & Co., Ltd.; 2005.
9.
go back to reference The Japanese Society for Cancer of the Colon and Rectum. JSCCR guidelines 2010 for the treatment of colorectal cancer. Tokyo: Kanehara & Co., Ltd.; 2010. The Japanese Society for Cancer of the Colon and Rectum. JSCCR guidelines 2010 for the treatment of colorectal cancer. Tokyo: Kanehara & Co., Ltd.; 2010.
10.
go back to reference Watanabe T, Itabashi M, Shimada Y, Tanaka S, Ito Y, Ajioka Y, et al. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer. Int J Clin Oncol. 2012;17:1–29.CrossRefPubMed Watanabe T, Itabashi M, Shimada Y, Tanaka S, Ito Y, Ajioka Y, et al. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer. Int J Clin Oncol. 2012;17:1–29.CrossRefPubMed
11.
go back to reference Sobin LHGM., Wittekind C. TNM classification of malignant tumours. 7th ed. New York: Wiley-Blackwell; 2009. Sobin LHGM., Wittekind C. TNM classification of malignant tumours. 7th ed. New York: Wiley-Blackwell; 2009.
13.
go back to reference Bae SU, Han YD, Cho MS, Hur H, Min BS, Baik SH, et al. Oncologic outcomes of colon cancer patients with extraregional lymph node metastasis: comparison of isolated paraaortic lymph node metastasis with resectable liver metastasis. Ann Surg Oncol. 2016;23:1562–8.CrossRefPubMed Bae SU, Han YD, Cho MS, Hur H, Min BS, Baik SH, et al. Oncologic outcomes of colon cancer patients with extraregional lymph node metastasis: comparison of isolated paraaortic lymph node metastasis with resectable liver metastasis. Ann Surg Oncol. 2016;23:1562–8.CrossRefPubMed
14.
go back to reference Kapiteijn E, Marijnen CA, Nagtegaal ID, Putter H, Steup WH, Wiggers T, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med. 2001;345:638–46.CrossRefPubMed Kapiteijn E, Marijnen CA, Nagtegaal ID, Putter H, Steup WH, Wiggers T, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med. 2001;345:638–46.CrossRefPubMed
15.
go back to reference Miyakura Y, Iwai H, Togashi K, Horie H, Nagai H, Kishaba Y, et al. Mucinous cystadenocarcinoma of the appendix invading the ascending colon with fistula formation: report of a case. Surg Today. 2007;37:806–10.CrossRefPubMed Miyakura Y, Iwai H, Togashi K, Horie H, Nagai H, Kishaba Y, et al. Mucinous cystadenocarcinoma of the appendix invading the ascending colon with fistula formation: report of a case. Surg Today. 2007;37:806–10.CrossRefPubMed
16.
go back to reference Tokunaga M, Ohyama S, Hiki N, Fukunaga T, Inoue H, Yamada K, et al. Therapeutic value of lymph node dissection in advanced gastric cancer with macroscopic duodenum invasion: is the posterior pancreatic head lymph node dissection beneficial? Ann Surg Oncol. 2009;16:1241–6.CrossRefPubMed Tokunaga M, Ohyama S, Hiki N, Fukunaga T, Inoue H, Yamada K, et al. Therapeutic value of lymph node dissection in advanced gastric cancer with macroscopic duodenum invasion: is the posterior pancreatic head lymph node dissection beneficial? Ann Surg Oncol. 2009;16:1241–6.CrossRefPubMed
17.
go back to reference Laurent C, Sa Cunha A, Rullier E, Smith D, Rullier A, Saric J. Impact of microscopic hepatic lymph node involvement on survival after resection of colorectal liver metastasis. J Am Coll Surg. 2004;198:884–91.CrossRefPubMed Laurent C, Sa Cunha A, Rullier E, Smith D, Rullier A, Saric J. Impact of microscopic hepatic lymph node involvement on survival after resection of colorectal liver metastasis. J Am Coll Surg. 2004;198:884–91.CrossRefPubMed
18.
go back to reference Viana EF, Herman P, Coelho FF, Taka TA, D’Albuquerque LA, Cecconello I. The role of hilar lymphadenectomy in patients subjected to hepatectomy due to colorectal metastasis. Arq Gastroenterol. 2011;48:217–9.CrossRefPubMed Viana EF, Herman P, Coelho FF, Taka TA, D’Albuquerque LA, Cecconello I. The role of hilar lymphadenectomy in patients subjected to hepatectomy due to colorectal metastasis. Arq Gastroenterol. 2011;48:217–9.CrossRefPubMed
20.
go back to reference Fidler IJ. Critical determinants of cancer metastasis: rationale for therapy. Cancer Chemother Pharmacol. 1999;43:S3–10.CrossRefPubMed Fidler IJ. Critical determinants of cancer metastasis: rationale for therapy. Cancer Chemother Pharmacol. 1999;43:S3–10.CrossRefPubMed
21.
go back to reference Morton DL, Cochran AJ, Thompson JF, Elashoff R, Essner R, Glass EC, et al. Sentinel node biopsy for early-stage melanoma: accuracy and morbidity in MSLT-I, an international multicenter trial. Ann Surg. 2005;242:302–11. (discussion 311–303).PubMedPubMedCentral Morton DL, Cochran AJ, Thompson JF, Elashoff R, Essner R, Glass EC, et al. Sentinel node biopsy for early-stage melanoma: accuracy and morbidity in MSLT-I, an international multicenter trial. Ann Surg. 2005;242:302–11. (discussion 311–303).PubMedPubMedCentral
22.
go back to reference Murawa D, Hirche C, Dresel S, Hunerbein M. Sentinel lymph node biopsy in breast cancer guided by indocyanine green fluorescence. Br J Surg. 2009;96:1289–94.CrossRefPubMed Murawa D, Hirche C, Dresel S, Hunerbein M. Sentinel lymph node biopsy in breast cancer guided by indocyanine green fluorescence. Br J Surg. 2009;96:1289–94.CrossRefPubMed
Metadata
Title
Additional lymph node dissection for primary colorectal cancer invading another colon region
Authors
Ryuma Tokunaga
Yasuo Sakamoto
Shigeki Nakagawa
Yuji Miyamoto
Naoya Yoshida
Hideo Baba
Publication date
01-07-2018
Publisher
Springer Singapore
Published in
Surgery Today / Issue 7/2018
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-018-1641-z

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