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Surgery Today
Published in: Surgery Today 2/2018

01-02-2018 | Original Article

The mean corpuscular volume as a prognostic factor for colorectal cancer

Authors: Hidemasa Nagai, Norihiro Yuasa, Eiji Takeuchi, Hideo Miyake, Yuichiro Yoshioka, Kanji Miyata

Published in: Surgery Today | Issue 2/2018

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Abstract

Purpose

The aim of the present study was to identify the factors investigated during routine blood examinations which can predict the disease outcome independent of the tumor stage.

Methods

Data from 1174 patients with stage I, II, and III CRC who underwent R0 resection were included. We investigated the correlations between the preoperative routine blood examination data, and clinicopathological factors, and disease-free survival (DFS) using univariate and multivariate analyses.

Results

The univariate analysis showed that tumor location, tumor stage, CRP, serum albumin, creatine kinase, neutrophil-to-lymphocyte ratio, red blood cell count, mean corpuscular volume (MCV), and the administration of postoperative adjuvant chemotherapy were significantly correlated with the DFS. The multivariate analysis of the factors associated with the DFS showed that stage and MCV were significant factors; an MCV of <80 fL was associated with a superior DFS in comparison to an MCV of 80–100 fL (hazard ratio: 0.31, 95% confidence interval: 0.13–0.61, p = 0.0003). The DFS in patients with an MCV of <80 fL was superior to that in patients with an MCV of ≥80 fL, irrespective of whether the patients underwent postoperative adjuvant chemotherapy.

Conclusion

MCV was a prognostic factor for the DFS, independent of the tumor stage, in CRC patients who underwent R0 resection.
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Metadata
Title
The mean corpuscular volume as a prognostic factor for colorectal cancer
Authors
Hidemasa Nagai
Norihiro Yuasa
Eiji Takeuchi
Hideo Miyake
Yuichiro Yoshioka
Kanji Miyata
Publication date
01-02-2018
Publisher
Springer Japan
Published in
Surgery Today / Issue 2/2018
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-017-1575-x

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