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Surgery Today
Published in: Surgery Today 9/2017

01-09-2017 | Original Article

Role of pulmonary metastasectomy in colorectal cancer in the era of modern multidisciplinary therapy

Authors: Ryu Kanzaki, Masayoshi Inoue, Toru Kimura, Tomohiro Kawamura, Soichiro Funaki, Yasushi Shintani, Masato Minami, Ichiro Takemasa, Tsunekazu Mizushima, Masaki Mori, Meinoshin Okumura

Published in: Surgery Today | Issue 9/2017

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Abstract

Purpose

To clarify the role of pulmonary metastasectomy in colorectal cancer in the era of modern multidisciplinary therapy.

Methods

The characteristics and outcomes of the patients who underwent pulmonary metastasectomy for colorectal cancer through 2002 (n = 26) and from 2003 (n = 68) were compared.

Results

The patients treated from 2003 had a smaller tumor size and more frequently had a history of extra-pulmonary relapses than did those treated through 2002. There was a significant improvement in the 5-year overall survival (42.0% vs. 73.1%, p = 0.03) but not the 5-year relapse-free survival (41.4% vs. 37.5%, p = 0.85) after pulmonary metastasectomy from 2003. The rate of patients who received local therapy with curative intent after the first pulmonary metastasectomy was significantly higher in patients treated from 2003 than in those treated through 2002 [4/13, (31%) vs. 25/39 (64%), p = 0.04]. The survival after relapse after the first pulmonary metastasectomy was significantly longer in patients treated from 2003 than in those treated through 2002 (median survival time: 14 vs. 47 months).

Conclusions

Pulmonary metastasectomy for colorectal cancer remains an important treatment option in the sense that it can achieve a good relapse-free survival.
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Metadata
Title
Role of pulmonary metastasectomy in colorectal cancer in the era of modern multidisciplinary therapy
Authors
Ryu Kanzaki
Masayoshi Inoue
Toru Kimura
Tomohiro Kawamura
Soichiro Funaki
Yasushi Shintani
Masato Minami
Ichiro Takemasa
Tsunekazu Mizushima
Masaki Mori
Meinoshin Okumura
Publication date
01-09-2017
Publisher
Springer Japan
Published in
Surgery Today / Issue 9/2017
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-017-1478-x

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