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Surgery Today
Published in: Surgery Today 6/2016

01-06-2016 | Original Article

Comparison of the risk of surgical site infection and feasibility of surgery between sennoside versus polyethylene glycol as a mechanical bowel preparation of elective colon cancer surgery: a randomized controlled trial

Authors: Yusuke Tajima, Hideyuki Ishida, Azusa Yamamoto, Noriyasu Chika, Hisashi Onozawa, Takeaki Matsuzawa, Kensuke Kumamoto, Keiichiro Ishibashi, Erito Mochiki

Published in: Surgery Today | Issue 6/2016

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Abstract

Purpose

To validate the usefulness of sennoside as a substitute for polyethylene glycol (PEG) as a mechanical bowel preparation (MBP) for elective colon cancer surgery.

Methods

We performed a prospective randomized non-inferiority trial comparing the use of sennoside and PEG in MBP for elective colon cancer surgery, in terms of the risk of surgical site infection (SSI) and the feasibility of surgery.

Results

The overall incidence of SSIs was 2.9 % in the sennoside group (n = 68) and 6.3 % in the PEG group (n = 63) with a difference of 3.4 % (95 % confidence interval 6.9–10.6 %). The intraoperative spillage of the stool materials in the sennoside and PEG groups was 4.4 and 3.1 %, respectively, and was not significantly different (p = 0.71), even the upstream stool consistency, was more frequently observed to be non-stool in the PEG group (65.1 vs. 30.9 %, p < 0.01).

Conclusion

MBP with sennoside could be a substitution for PEG in elective colon cancer surgery.
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Metadata
Title
Comparison of the risk of surgical site infection and feasibility of surgery between sennoside versus polyethylene glycol as a mechanical bowel preparation of elective colon cancer surgery: a randomized controlled trial
Authors
Yusuke Tajima
Hideyuki Ishida
Azusa Yamamoto
Noriyasu Chika
Hisashi Onozawa
Takeaki Matsuzawa
Kensuke Kumamoto
Keiichiro Ishibashi
Erito Mochiki
Publication date
01-06-2016
Publisher
Springer Japan
Published in
Surgery Today / Issue 6/2016
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-015-1239-7

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