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Open Access 01-05-2016 | Original Article

Correlation between histological invasiveness and the computed tomography value in pure ground-glass nodules

Authors: Akihiko Kitami, Fumitoshi Sano, Shoko Hayashi, Kosuke Suzuki, Shugo Uematsu, Yoshito Kamio, Takashi Suzuki, Mitsutaka Kadokura, Mutsuko Omatsu, Toshiaki Kunimura

Published in: Surgery Today | Issue 5/2016

Abstract

Purpose

The purpose of this study was to evaluate the correlation between histological invasiveness and the computed tomography (CT) value and size in pure ground-glass nodules (GGNs) to determine optimal “follow-up or resection” strategies.

Methods

Between 2001 and 2014, 78 resected, pure GGNs were retrospectively evaluated. The maximum diameter and CT value of pure GGNs were measured using a computer graphics support system.

Results

All GGNs with a maximum diameter ≤10 mm and CT value ≤−600 Hounsfield units (HU) were considered to be noninvasive lesions, while 21 of 26 (81 %) with a maximum diameter >10 mm and CT value >−600 HU were considered to be invasive lesions. With respect to the correlation between each histological type and pure GGN with a maximum diameter ≤10 mm and CT value ≤−600 HU, the specificity was 90 % and the sensitivity and negative predictive value were both 100 % in atypical adenomatous hyperplasia (AAH), while the specificity was 58 % and the sensitivity and positive predictive value were 0 % in minimally invasive and invasive adenocarcinoma.

Conclusion

Pure GGNs with a maximum diameter of ≤10 mm and CT value of ≤−600 HU are nearly always pre-invasive lesions; therefore, surgery should be carefully selected in such patients.

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Title: Correlation between histological invasiveness and the computed tomography value in pure ground-glass nodules
Authors: Akihiko Kitami
Fumitoshi Sano
Shoko Hayashi
Kosuke Suzuki
Shugo Uematsu
Yoshito Kamio
Takashi Suzuki
Mitsutaka Kadokura
Mutsuko Omatsu
Toshiaki Kunimura
Publication date: 01-05-2016
Publisher: Springer Japan
Published in: Surgery Today / Issue 5/2016
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-015-1208-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Correlation between histological invasiveness and the computed tomography value in pure ground-glass nodules

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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