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Surgery Today
Published in: Surgery Today 1/2016

01-01-2016 | Original Article

Distribution of interstitial pneumonia: a new radiological predictor of 90-day mortality after resection of lung cancer

Authors: Mariko Fukui, Kenji Suzuki, Shiaki Oh, Takeshi Matsunaga, Yoshikazu Miyasaka, Izumi Kawagoe, Kazuya Takamochi

Published in: Surgery Today | Issue 1/2016

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Abstract

Background

Surgery for lung cancer complicated by idiopathic interstitial pneumonia (IIP) is associated with a high rate of postoperative mortality. Thus, preoperative predictors of surgical mortality are needed to aid in the selection of suitable surgical candidates.

Methods

The subjects of this retrospective study were 1625 patients who underwent resection of primary lung cancer between 2000 and 2012, 203 (12.5 %) of whom were found to have IIPs. The following radiological findings were also evaluated: presence of honeycombing and the distribution (diffuse or localized) and extension (central extension or peripheral localized) of honeycombing or infiltration. We also investigated clinical factors and conducted multivariate analyses to identify the predictors of surgical mortality.

Results

The 30- and 90-day mortality rates were 0.5 and 1.4 % overall and 1.6 and 6.4 % in the IIP patients, respectively. Multivariate analysis revealed that a preoperative pO2 < 70 mmHg (HR 15.3), diffuse distribution and central extension of interstitial pneumonia on computed tomography (HR 9.2), and operative blood loss (ml: HR 1.003) were significant predictors of 90-day mortality.

Conclusions

Diffuse distribution and central extension of IIPs, as well as preoperative hypoxia and operative blood loss, were significant predictors of 90-day mortality.
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Metadata
Title
Distribution of interstitial pneumonia: a new radiological predictor of 90-day mortality after resection of lung cancer
Authors
Mariko Fukui
Kenji Suzuki
Shiaki Oh
Takeshi Matsunaga
Yoshikazu Miyasaka
Izumi Kawagoe
Kazuya Takamochi
Publication date
01-01-2016
Publisher
Springer Japan
Published in
Surgery Today / Issue 1/2016
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-015-1143-1

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