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Surgery Today
Published in: Surgery Today 4/2015

01-04-2015 | Original Article

Implications of peritoneal lavage cytology in resectable left-sided pancreatic cancer

Authors: Yoshifumi Iwagami, Hidetoshi Eguchi, Hiroshi Wada, Yoshito Tomimaru, Naoki Hama, Koichi Kawamoto, Shogo Kobayashi, Masaki Mori, Yuichiro Doki, Hiroaki Nagano

Published in: Surgery Today | Issue 4/2015

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Abstract

Purpose

The aim of this study was to determine the utility of the peritoneal lavage cytology findings in predicting the clinical outcomes of resectable left-sided pancreatic cancer.

Methods

Peritoneal lavage samples were collected from 39 consecutive patients who underwent surgery for left-sided pancreatic cancer between January 2000 and December 2010. We analyzed the correlations between the peritoneal lavage cytology findings and the clinical outcomes.

Results

Five patients (12.8 %) had malignant cells in the cytology samples (positive cytology). This occurred more frequently in patients with vascular invasion (P = 0.008). Positive cytology was significantly associated with lower overall (P = 0.0007) and recurrent-free (P < 0.0001) survival rates. Positive cytology was an independent prognostic factor for recurrence (P = 0.022); it was closely associated with local recurrence, peritoneal recurrence and distant metastasis.

Conclusion

Surgeons should carefully consider the intraoperative diagnosis of peritoneal lavage cytology in patients with resectable left-sided pancreatic cancers, because patients with positive cytology are likely to experience recurrence.
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Metadata
Title
Implications of peritoneal lavage cytology in resectable left-sided pancreatic cancer
Authors
Yoshifumi Iwagami
Hidetoshi Eguchi
Hiroshi Wada
Yoshito Tomimaru
Naoki Hama
Koichi Kawamoto
Shogo Kobayashi
Masaki Mori
Yuichiro Doki
Hiroaki Nagano
Publication date
01-04-2015
Publisher
Springer Japan
Published in
Surgery Today / Issue 4/2015
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-014-0964-7

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