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01-04-2015 | Case Report

Impaired wound healing and expansion of a large ulcer after bevacizumab with paclitaxel for skin metastases from breast cancer: report of a case

Authors: Yuko Kijima, Heiji Yoshinaka, Munetsugu Hirata, Akihiro Nakajo, Hideo Arima, Yoshiaki Shinden, Tetsuya Ijichi, Yuka Eguchi, Hiroshi Okumura, Yoshikazu Uenosono, Hiroshi Kurahara, Sumiya Ishigami, Shoji Natsugoe

Published in: Surgery Today | Issue 4/2015

Abstract

A 48-year-old Japanese woman was found to have local recurrence of breast cancer in the chest wall following neoadjuvant chemotherapy, total mastectomy with axillary lymphadenectomy, postoperative radiation therapy to the chest wall, and adjuvant systemic therapy using trastuzumab. As a third line of treatment after recurrence, bevacizumab with paclitaxel was initiated for several metastatic lesions on the skin of the chest wall, left internal costal lymph nodes, and right axillary lymph nodes. The wound on the chest wall continued to expand in diameter and depth after the third course of bevacizumab with paclitaxel until the rib was exposed. After stopping the bevacizumab, granulation tissue expanded and by 3 months, had covered the bottom of the ulcer. The patient died soon thereafter, despite systemic chemotherapy with eribulin; however, there was no further bleeding from the ulcer on the chest wall or the exposed ribs.

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Title: Impaired wound healing and expansion of a large ulcer after bevacizumab with paclitaxel for skin metastases from breast cancer: report of a case
Authors: Yuko Kijima
Heiji Yoshinaka
Munetsugu Hirata
Akihiro Nakajo
Hideo Arima
Yoshiaki Shinden
Tetsuya Ijichi
Yuka Eguchi
Hiroshi Okumura
Yoshikazu Uenosono
Hiroshi Kurahara
Sumiya Ishigami
Shoji Natsugoe
Publication date: 01-04-2015
Publisher: Springer Japan
Published in: Surgery Today / Issue 4/2015
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-014-0912-6

At a glance: The STEP trials

Springer Medicine

Impaired wound healing and expansion of a large ulcer after bevacizumab with paclitaxel for skin metastases from breast cancer: report of a case

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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