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Published in: Surgery Today 12/2014

01-12-2014 | Original Article

Risk factors for conversion of laparoscopic cholecystectomy to open surgery associated with the severity characteristics according to the Tokyo guidelines

Authors: Koji Asai, Manabu Watanabe, Shinya Kusachi, Hiroshi Matsukiyo, Tomoaki Saito, Hajime Kodama, Takaharu Kiribayashi, Toshiyuki Enomoto, Yoichi Nakamura, Yasushi Okamoto, Yoshihisa Saida, Jiro Nagao

Published in: Surgery Today | Issue 12/2014

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Abstract

Purpose

The aim of this retrospective study was to identify the risk factors associated with the severity characteristics in the Tokyo guidelines for conversion to open surgery in patients with acute cholecystitis (AC) who underwent laparoscopic cholecystectomy.

Methods

A total of 225 patients were enrolled in the study. The patients were classified into two groups: a conversion group and a no-conversion group. The preoperative characteristics and therapeutic strategy were analyzed as risk factors for conversion to open surgery. The postoperative outcomes were also analyzed.

Results

Conversion to open surgery occurred in 29 patients (12.9 %), including seven patients (6.7 %) with mild AC and 22 patients (18.5 %) with moderate AC. A univariate analysis showed that the risk factors for conversion to open surgery included a duration of symptoms longer than 72 h, an elevated C-reactive protein (CRP) value and the Tokyo guidelines 2013 (TG 13) severity classification. The multivariate analysis showed that the risk factors for conversion to open surgery included a duration of symptoms longer than 72 h and a CRP value >11.5 mg/dl.

Conclusions

A duration of symptoms longer than 72 h, which is included in the criterion for moderate AC severity in the TG 13, was an independent risk factor for conversion to open surgery. In addition, adoption of a high CRP value as an additional criterion for moderate AC may increase the utility of the TG 13.
Literature
1.
go back to reference Gracie WA, Ransohoff DF. The natural history of silent gallstones: the innocent gallstone is not a myth. N Engl J Med. 1982;307:798–800.PubMedCrossRef Gracie WA, Ransohoff DF. The natural history of silent gallstones: the innocent gallstone is not a myth. N Engl J Med. 1982;307:798–800.PubMedCrossRef
2.
go back to reference Kum CK, Eypasch E, Lefering R, Paul A, Neugebauer E, Troidl H. Laparoscopic cholecystectomy for acute cholecystitis: is it really safe? World J Surg. 1996;20:43–8 (discussion 48-9).PubMedCrossRef Kum CK, Eypasch E, Lefering R, Paul A, Neugebauer E, Troidl H. Laparoscopic cholecystectomy for acute cholecystitis: is it really safe? World J Surg. 1996;20:43–8 (discussion 48-9).PubMedCrossRef
3.
go back to reference Takada T, Kawarada Y, Nimura Y, Yoshida M, Mayumi T, Sekimoto M, et al. Background: Tokyo guidelines for the management of acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Surg. 2007;14:1–10.PubMedCentralPubMedCrossRef Takada T, Kawarada Y, Nimura Y, Yoshida M, Mayumi T, Sekimoto M, et al. Background: Tokyo guidelines for the management of acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Surg. 2007;14:1–10.PubMedCentralPubMedCrossRef
4.
go back to reference Hirota M, Takada T, Kawarada Y, Nimura Y, Miura F, Hirata K, et al. Diagnostic criteria and severity assessment of acute cholecystitis: Tokyo guidelines. J Hepatobiliary Pancreat Surg. 2007;14:78–82.PubMedCentralPubMedCrossRef Hirota M, Takada T, Kawarada Y, Nimura Y, Miura F, Hirata K, et al. Diagnostic criteria and severity assessment of acute cholecystitis: Tokyo guidelines. J Hepatobiliary Pancreat Surg. 2007;14:78–82.PubMedCentralPubMedCrossRef
5.
go back to reference Yamashita Y, Takada T, Kawarada Y, Nimura Y, Hirota M, Miura F, et al. Surgical treatment of patients with acute cholecystitis: Tokyo guidelines. J Hepatobiliary Pancreat Surg. 2007;14:91–7.PubMedCentralPubMedCrossRef Yamashita Y, Takada T, Kawarada Y, Nimura Y, Hirota M, Miura F, et al. Surgical treatment of patients with acute cholecystitis: Tokyo guidelines. J Hepatobiliary Pancreat Surg. 2007;14:91–7.PubMedCentralPubMedCrossRef
6.
go back to reference Takada T, Strasberg SM, Solomkin JS, Pitt HA, Gomi H, Yoshida M, et al. TG13: Updated Tokyo guidelines for the management of acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Sci. 2013;20:1–7.PubMedCrossRef Takada T, Strasberg SM, Solomkin JS, Pitt HA, Gomi H, Yoshida M, et al. TG13: Updated Tokyo guidelines for the management of acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Sci. 2013;20:1–7.PubMedCrossRef
7.
go back to reference Yokoe M, Takada T, Strasberg SM, Solomkin JS, Mayumi T, Gomi H, et al. TG13 diagnostic criteria and severity grading of acute cholecystitis. J Hepatobiliary Pancreat Sci. 2013;20:35–46.PubMedCrossRef Yokoe M, Takada T, Strasberg SM, Solomkin JS, Mayumi T, Gomi H, et al. TG13 diagnostic criteria and severity grading of acute cholecystitis. J Hepatobiliary Pancreat Sci. 2013;20:35–46.PubMedCrossRef
8.
go back to reference Yamashita Y, Takada T, Strasberg SM, Pitt HA, Gouma DJ, Garden OJ, et al. TG13 surgical management of acute cholecystitis. J Hepatobiliary Pancreat Sci. 2013;20:89–96.PubMedCrossRef Yamashita Y, Takada T, Strasberg SM, Pitt HA, Gouma DJ, Garden OJ, et al. TG13 surgical management of acute cholecystitis. J Hepatobiliary Pancreat Sci. 2013;20:89–96.PubMedCrossRef
9.
go back to reference Johansson M, Thune A, Nelvin L, Stiernstam M, Westman B, Lundell L. Randomized clinical trial of open versus laparoscopic cholecystectomy in the treatment of acute cholecystitis. Br J Surg. 2005;92:44–9.PubMedCrossRef Johansson M, Thune A, Nelvin L, Stiernstam M, Westman B, Lundell L. Randomized clinical trial of open versus laparoscopic cholecystectomy in the treatment of acute cholecystitis. Br J Surg. 2005;92:44–9.PubMedCrossRef
10.
go back to reference Lai PB, Kwong KH, Leung KL, Kwok SP, Chan AC, Chung SC, et al. Randomized trial of early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Br J Surg. 1998;85:764–7.PubMedCrossRef Lai PB, Kwong KH, Leung KL, Kwok SP, Chan AC, Chung SC, et al. Randomized trial of early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Br J Surg. 1998;85:764–7.PubMedCrossRef
11.
go back to reference Lo CM, Liu CL, Fan ST, Lai EC, Wong J. Prospective randomized study of early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Ann Surg. 1998;227:461–7.PubMedCentralPubMedCrossRef Lo CM, Liu CL, Fan ST, Lai EC, Wong J. Prospective randomized study of early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Ann Surg. 1998;227:461–7.PubMedCentralPubMedCrossRef
12.
go back to reference Johansson M, Thune A, Blomqvist A, Nelvin L, Lundell L. Management of acute cholecystitis in the laparoscopic era: results of a prospective, randomized clinical trial. J Gastrointest Surg. 2003;7:642–5.PubMedCrossRef Johansson M, Thune A, Blomqvist A, Nelvin L, Lundell L. Management of acute cholecystitis in the laparoscopic era: results of a prospective, randomized clinical trial. J Gastrointest Surg. 2003;7:642–5.PubMedCrossRef
13.
go back to reference Kolla SB, Aggarwal S, Kumar A, Kumar R, Chumber S, Parshad R, et al. Early versus delayed laparoscopic cholecystectomy for acute cholecystitis: a prospective randomized trial. Surg Endosc. 2004;18:1323–7.PubMedCrossRef Kolla SB, Aggarwal S, Kumar A, Kumar R, Chumber S, Parshad R, et al. Early versus delayed laparoscopic cholecystectomy for acute cholecystitis: a prospective randomized trial. Surg Endosc. 2004;18:1323–7.PubMedCrossRef
14.
go back to reference Gurusamy K, Samraj K, Gluud C, Wilson E, Davidson BR. Meta-analysis of randomized controlled trials on the safety and effectiveness of early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Br J Surg. 2010;97:141–50.PubMedCrossRef Gurusamy K, Samraj K, Gluud C, Wilson E, Davidson BR. Meta-analysis of randomized controlled trials on the safety and effectiveness of early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Br J Surg. 2010;97:141–50.PubMedCrossRef
15.
go back to reference Banz V, Gsponer T, Candinas D, Guller U. Population-based analysis of 4113 patients with acute cholecystitis: defining the optimal time-point for laparoscopic cholecystectomy. Ann Surg. 2011;254:964–70.PubMedCrossRef Banz V, Gsponer T, Candinas D, Guller U. Population-based analysis of 4113 patients with acute cholecystitis: defining the optimal time-point for laparoscopic cholecystectomy. Ann Surg. 2011;254:964–70.PubMedCrossRef
16.
go back to reference Halachmi S, DiCastro N, Matter I, Cohen A, Sabo E, Mogilner JG, et al. Laparoscopic cholecystectomy for acute cholecystitis: how do fever and leucocytosis relate to conversion and complications? Eur J Surg. 2000;166:136–40.PubMedCrossRef Halachmi S, DiCastro N, Matter I, Cohen A, Sabo E, Mogilner JG, et al. Laparoscopic cholecystectomy for acute cholecystitis: how do fever and leucocytosis relate to conversion and complications? Eur J Surg. 2000;166:136–40.PubMedCrossRef
17.
go back to reference Lo CM, Fan ST, Liu CL, Lai EC, Wong J. Early decision for conversion of laparoscopic to open cholecystectomy for treatment of acute cholecystitis. Am J Surg. 1997;173:513–7.PubMedCrossRef Lo CM, Fan ST, Liu CL, Lai EC, Wong J. Early decision for conversion of laparoscopic to open cholecystectomy for treatment of acute cholecystitis. Am J Surg. 1997;173:513–7.PubMedCrossRef
18.
go back to reference Popkharitov AI. Laparoscopic cholecystectomy for acute cholecystitis. Langenbecks Arch Surg. 2008;393:935–41.PubMedCrossRef Popkharitov AI. Laparoscopic cholecystectomy for acute cholecystitis. Langenbecks Arch Surg. 2008;393:935–41.PubMedCrossRef
19.
go back to reference Brodsky A, Matter I, Sabo E, Cohen A, Abrahamson J, Eldar S. Laparoscopic cholecystectomy for acute cholecystitis: can the need for conversion and the probability of complications be predicted? A prospective study. Surg Endosc. 2000;14:755–60.PubMedCrossRef Brodsky A, Matter I, Sabo E, Cohen A, Abrahamson J, Eldar S. Laparoscopic cholecystectomy for acute cholecystitis: can the need for conversion and the probability of complications be predicted? A prospective study. Surg Endosc. 2000;14:755–60.PubMedCrossRef
20.
go back to reference Hadad SM, Vaidya JS, Baker L, Koh HC, Heron TP, Hussain K, et al. Delay from symptom onset increases the conversion rate in laparoscopic cholecystectomy for acute cholecystitis. World J Surg. 2007;31:1298–301 (discussion 1302–3.)PubMedCrossRef Hadad SM, Vaidya JS, Baker L, Koh HC, Heron TP, Hussain K, et al. Delay from symptom onset increases the conversion rate in laparoscopic cholecystectomy for acute cholecystitis. World J Surg. 2007;31:1298–301 (discussion 1302–3.)PubMedCrossRef
21.
go back to reference Wevers KP, van Westreenen HL, Patijn GA. Laparoscopic cholecystectomy in acute cholecystitis: C-reactive protein level combined with age predicts conversion. Surg Laparosc Endosc Percutan Tech. 2013;23:163–6.PubMedCrossRef Wevers KP, van Westreenen HL, Patijn GA. Laparoscopic cholecystectomy in acute cholecystitis: C-reactive protein level combined with age predicts conversion. Surg Laparosc Endosc Percutan Tech. 2013;23:163–6.PubMedCrossRef
22.
go back to reference Reibetanz J, Ickrath P, Hain J, Germer CT, Krajinovic K. Single-port laparoscopic cholecystectomy versus standard multiport laparoscopic cholecystectomy: a case-control study comparing the long-term quality of life and body image. Surg Today. 2013;43:1025–30.PubMedCrossRef Reibetanz J, Ickrath P, Hain J, Germer CT, Krajinovic K. Single-port laparoscopic cholecystectomy versus standard multiport laparoscopic cholecystectomy: a case-control study comparing the long-term quality of life and body image. Surg Today. 2013;43:1025–30.PubMedCrossRef
23.
go back to reference Asai K, Watanabe M, Kusachi S, Matsukiyo H, Saito T, Kodama H, et al. Changes in the therapeutic strategy for acute cholecystitis after the Tokyo guidelines were published. J Hepatobiliary Pancreat Sci. 2013;20:348–55.PubMedCrossRef Asai K, Watanabe M, Kusachi S, Matsukiyo H, Saito T, Kodama H, et al. Changes in the therapeutic strategy for acute cholecystitis after the Tokyo guidelines were published. J Hepatobiliary Pancreat Sci. 2013;20:348–55.PubMedCrossRef
24.
go back to reference Schafer M, Krahenbuhl L, Buchler MW. Predictive factors for the type of surgery in acute cholecystitis. Am J Surg. 2001;182:291–7.PubMedCrossRef Schafer M, Krahenbuhl L, Buchler MW. Predictive factors for the type of surgery in acute cholecystitis. Am J Surg. 2001;182:291–7.PubMedCrossRef
25.
go back to reference Teckchandani N, Garg PK, Hadke NS, Jain SK, Kant R, Mandal AK, et al. Predictive factors for successful early laparoscopic cholecystectomy in acute cholecystitis: a prospective study. Int J Surg. 2010;8:623–7.PubMedCrossRef Teckchandani N, Garg PK, Hadke NS, Jain SK, Kant R, Mandal AK, et al. Predictive factors for successful early laparoscopic cholecystectomy in acute cholecystitis: a prospective study. Int J Surg. 2010;8:623–7.PubMedCrossRef
26.
go back to reference Asai K, Watanabe M, Kusachi S, Tanaka H, Matsukiyo H, Osawa A, et al. Bacteriological analysis of bile in acute cholecystitis according to the Tokyo guidelines. J Hepatobiliary Pancreat Sci. 2012;19:476–86.PubMedCrossRef Asai K, Watanabe M, Kusachi S, Tanaka H, Matsukiyo H, Osawa A, et al. Bacteriological analysis of bile in acute cholecystitis according to the Tokyo guidelines. J Hepatobiliary Pancreat Sci. 2012;19:476–86.PubMedCrossRef
27.
go back to reference Lee SW, Chang CS, Lee TY, Tung CF, Peng YC. The role of the Tokyo guidelines in the diagnosis of acute calculous cholecystitis. J Hepatobiliary Pancreat Sci. 2010;17:879–84.PubMedCrossRef Lee SW, Chang CS, Lee TY, Tung CF, Peng YC. The role of the Tokyo guidelines in the diagnosis of acute calculous cholecystitis. J Hepatobiliary Pancreat Sci. 2010;17:879–84.PubMedCrossRef
28.
go back to reference Moyson J, Thill V, Simoens C, Smets D, Debergh N, Mendes da Costa P. Laparoscopic cholecystectomy for acute cholecystitis in the elderly: a retrospective study of 100 patients. Hepatogastroenterology. 2008;55:1975–80.PubMed Moyson J, Thill V, Simoens C, Smets D, Debergh N, Mendes da Costa P. Laparoscopic cholecystectomy for acute cholecystitis in the elderly: a retrospective study of 100 patients. Hepatogastroenterology. 2008;55:1975–80.PubMed
Metadata
Title
Risk factors for conversion of laparoscopic cholecystectomy to open surgery associated with the severity characteristics according to the Tokyo guidelines
Authors
Koji Asai
Manabu Watanabe
Shinya Kusachi
Hiroshi Matsukiyo
Tomoaki Saito
Hajime Kodama
Takaharu Kiribayashi
Toshiyuki Enomoto
Yoichi Nakamura
Yasushi Okamoto
Yoshihisa Saida
Jiro Nagao
Publication date
01-12-2014
Publisher
Springer Japan
Published in
Surgery Today / Issue 12/2014
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-014-0838-z

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