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01-07-2014 | Original Article

The DNA index is a strong predictive marker in intrahepatic cholangiocarcinoma: the results of a five-year prospective study

Authors: Carsten Kamphues, Nadine Al-Abadi, Angelika Dürr, Roberta Bova, Frederick Klauschen, Albrecht Stenzinger, Marcus Bahra, Hussein Al-Abadi, Peter Neuhaus, Daniel Seehofer

Published in: Surgery Today | Issue 7/2014

Abstract

Purpose

Predictive markers for risk stratification among patients with intrahepatic cholangiocarcinoma (IHC) are still lacking. Therefore, recent studies have focused on identifying the biological aspects of tumors that can provide more information about the tumor aggressiveness. The aim of this study was to prospectively evaluate the prognostic potential of the DNA index in patients undergoing liver resection for IHC.

Methods

In a prospective long-term follow-up study, the DNA index of 65 IHC patients undergoing liver resection was assessed by DNA image cytometry, and this parameter, as well as standard histopathological parameters, correlated with the patient survival.

Results

The mean DNA index was 1.69 ± 0.66 (range, 0.9–4.3). The univariate survival analysis showed that the DNA index (p = 0.024) and tumor stage (p = 0.017) were associated with patient survival, whereas all other standard histopathological factors had no predictive value. The multivariate analysis identified the DNA index (p = 0.050) and tumor stage (p = 0.028) as independent prognostic parameters.

Conclusions

The DNA index is an independent predictive marker for IHC after liver resection. It is superior to most standard histopathological parameters and can be assessed pre- and postoperatively. Therefore, the DNA index might represent a promising tool in the decision-making process for patients with IHC.

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Title: The DNA index is a strong predictive marker in intrahepatic cholangiocarcinoma: the results of a five-year prospective study
Authors: Carsten Kamphues
Nadine Al-Abadi
Angelika Dürr
Roberta Bova
Frederick Klauschen
Albrecht Stenzinger
Marcus Bahra
Hussein Al-Abadi
Peter Neuhaus
Daniel Seehofer
Publication date: 01-07-2014
Publisher: Springer Japan
Published in: Surgery Today / Issue 7/2014
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-013-0701-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The DNA index is a strong predictive marker in intrahepatic cholangiocarcinoma: the results of a five-year prospective study

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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