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Surgery Today
Published in: Surgery Today 4/2014

01-04-2014 | Review Article

Accuracy of sentinel node biopsy in esophageal carcinoma: a systematic review and meta-analysis of the pertinent literature

Authors: Vahid Reza Dabbagh Kakhki, Reza Bagheri, Shahrzad Tehranian, Pardis Shojaei, Hassan Gholami, Ramin Sadeghi, David N. Krag

Published in: Surgery Today | Issue 4/2014

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Abstract

The use of sentinel node surgery for esophageal carcinoma is still under investigation. We evaluated the data available in the literature on this topic, and herein present the results in a systematic review format. PUBMED, SCOPUS, the ISI web of knowledge and the information from the annual meetings of the Japan Esophageal Society were searched using the search terms: “(esophagus OR esophageal) AND sentinel”. The outcomes of interest were the detection rate and sensitivity. Overall, 18 studies were included. The pooled detection rate was 89.2 % [82.6–93.5]. Patients with T1 and two tumors had a 17 % higher detection rate compared to those with T3 and four tumors. The pooled sensitivity was 84 % [78–88 %]. The sensitivity was higher for adenocarcinoma compared to squamous cell carcinoma (SCC) (91 vs. 81 %). In the SCC patients, there was a trend toward decreased sensitivity associated with an increasing tumor depth (T1:88 %, T2:76 %, T3:50 %). Our analysis indicated that sentinel node biopsy is useful in adenocarcinoma patients. For SCC patients, including only cN0 patients (preferably T1 and 2) would increase the detection rate and sensitivity. Due to the limited number of high-quality studies, drawing any more definite conclusions is impossible. Large cohort studies with a standardized and consistent design will be needed in the future.
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Metadata
Title
Accuracy of sentinel node biopsy in esophageal carcinoma: a systematic review and meta-analysis of the pertinent literature
Authors
Vahid Reza Dabbagh Kakhki
Reza Bagheri
Shahrzad Tehranian
Pardis Shojaei
Hassan Gholami
Ramin Sadeghi
David N. Krag
Publication date
01-04-2014
Publisher
Springer Japan
Published in
Surgery Today / Issue 4/2014
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-013-0590-9

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