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Surgery Today

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01-09-2013 | Original Article

Clinical features and management of pouchitis in Japanese ulcerative colitis patients

Authors: Motoi Uchino, Hiroki Ikeuchi, Hiroki Matsuoka, Toshihiro Bando, Yoshio Takesue, Naohiro Tomita

Published in: Surgery Today | Issue 9/2013

Abstract

Purpose

Pouchitis frequently occurs after restorative proctocolectomy for ulcerative colitis. This study evaluated the incidence and treatment of pouchitis in Japanese ulcerative colitis patients.

Method

This study reviewed the clinical data from 772 patients with pouch surgery between January 2000 and December 2010. Pouchitis was classified as acute or chronic pouchitis. The potential preoperative risk factors for overall and chronic pouchitis were analyzed using a logistic regression analysis.

Result

The incidence of overall pouchitis and the cumulative risk of developing overall pouchitis were 10.0 % (77/772) and 10.7 % after 10 years, respectively. In addition, 74.0 % of all patients who developed overall pouchitis did so within 2 years after surgery. Chronic pouchitis occurred in 37.7 %. Although no independent risk factor for overall pouchitis was found, age at the onset of ulcerative colitis <26 years and surgical indications of toxic megacolon were found to be risk factors for chronic pouchitis and surgical indications of cancer/dysplasia were significantly associated with a low risk of overall pouchitis and patients with cancer/dysplasia were older than patients with other surgical indications (p < 0.01).

Conclusion

Immune abnormalities in younger onset patients or toxic megacolon may be more significant than surgical indications of cancer/dysplasia in elderly patients. Fundamental immune abnormalities may remain even after proctocolectomy.

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Title: Clinical features and management of pouchitis in Japanese ulcerative colitis patients
Authors: Motoi Uchino
Hiroki Ikeuchi
Hiroki Matsuoka
Toshihiro Bando
Yoshio Takesue
Naohiro Tomita
Publication date: 01-09-2013
Publisher: Springer Japan
Published in: Surgery Today / Issue 9/2013
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-012-0377-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Clinical features and management of pouchitis in Japanese ulcerative colitis patients

Abstract

Purpose

Method

Result

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Method

Result

Conclusion

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