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01-02-2012 | Case Report

Tissue engineered myoblast sheets improved cardiac function sufficiently to discontinue LVAS in a patient with DCM: report of a case

Authors: Yoshiki Sawa, Shigeru Miyagawa, Taichi Sakaguchi, Tomoyuki Fujita, Akifumi Matsuyama, Atsuhiro Saito, Tatsuya Shimizu, Teruo Okano

Published in: Surgery Today | Issue 2/2012

Abstract

Dilated cardiomyopathy (DCM) is a heart muscle disease characterized by progressive heart failure, and is a leading cause of mortality and morbidity. Recently, cellular therapy for end-stage heart failure has been emerging. We herein report a 56-year-old male who received a transplant of autologous myoblast sheets manufactured in temperature-responsive culture dishes. His clinical condition improved markedly, leaving him without any arrhythmia and able to discontinue using a left ventricular assist system and avoid cardiac transplantation. These findings suggest that cellular therapy using myoblast sheets is a promising new strategy for treating patients with end-stage DCM. This method might be an effective alternative to heart transplantation in the near future.

Dandel M, Weng Y, Siniawski H, Potapov E, Lehmkuhl HB, Hetzer R. Long-term results in patients with idiopathic dilated cardiomyopathy after weaning from left ventricular assist devices. Circulation. 2005;112:I37–45.PubMedCrossRef

Hata H, Matsumiya G, Miyagawa S, et al. Grafted skeletal myoblast sheets attenuate myocardial remodeling in pacing-induced canine heart failure model. J Thorac Cardiovasc Surg. 2006;132:918–24.PubMedCrossRef

Menasche P, Alfieri O, Janssens S, et al. The myoblast autologous grafting in ischemic cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation. Circulation. 2008;117:1189–200.PubMedCrossRef

Memon IA, Sawa Y, Fukushima N, et al. Repair of impaired myocardium by means of implantation of engineered autologous myoblast sheets. J Thorac Cardiovasc Surg. 2005;130:1333–41.PubMedCrossRef

Miyagawa S, Sawa Y, Sakakida S, et al. Tissue cardiomyoplasty using bioengineered contractile cardiomyocyte sheets to repair damaged myocardium: their integration with recipient myocardium. Transplantation. 2005;80:1586–95.PubMedCrossRef

Title: Tissue engineered myoblast sheets improved cardiac function sufficiently to discontinue LVAS in a patient with DCM: report of a case
Authors: Yoshiki Sawa
Shigeru Miyagawa
Taichi Sakaguchi
Tomoyuki Fujita
Akifumi Matsuyama
Atsuhiro Saito
Tatsuya Shimizu
Teruo Okano
Publication date: 01-02-2012
Publisher: Springer-Verlag
Published in: Surgery Today / Issue 2/2012
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-011-0106-4

At a glance: The STEP trials

Springer Medicine

Tissue engineered myoblast sheets improved cardiac function sufficiently to discontinue LVAS in a patient with DCM: report of a case

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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