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Surgery Today

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01-07-2012 | Original Article

The effects of the early administration of sivelestat sodium, a selective neutrophil elastase inhibitor, on the postoperative course after radical surgery for esophageal cancer

Authors: Junichi Nishiyama, Mitsumasa Matsuda, Satoko Ando, Miyoko Hirasawa, Toshiyasu Suzuki, Hiroyasu Makuuchi

Published in: Surgery Today | Issue 7/2012

Abstract

Purpose

The goal of this retrospective study was to evaluate the effects of perioperative administration of sivelestat sodium hydrate, a selective neutrophil elastase inhibitor, on the clinical course after radical surgery for esophageal cancer.

Methods

The effects of sivelestat on postoperative systemic inflammatory reactions and respiratory function were examined in 53 patients who underwent radical surgery for esophageal cancer between April 2004 and March 2005 with (n = 26, sivelestat group) and without (n = 27, control group) the administration of sivelestat.

Results

The average age in the sivelestat group was higher than that in the control group, but there were no other differences in the background factors between the two groups. The postoperative oxygenation (PaO₂/FiO₂ ratio) did not differ between the groups, but the decrease in oxygen saturation (SpO₂) was significantly inhibited in the sivelestat group compared with the control group (p < 0.01). A significant inhibition of the increase in the CRP level also occurred in the sivelestat group (p < 0.01). The patients in the sivelestat group were also hospitalized for shorter periods compared to those in the control group.

Conclusion

The early administration of sivelestat to patients receiving radical surgery for esophageal cancer can inhibit postoperative systemic inflammatory reactions and it might also have a beneficial effect on the prognosis.

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Title: The effects of the early administration of sivelestat sodium, a selective neutrophil elastase inhibitor, on the postoperative course after radical surgery for esophageal cancer
Authors: Junichi Nishiyama
Mitsumasa Matsuda
Satoko Ando
Miyoko Hirasawa
Toshiyasu Suzuki
Hiroyasu Makuuchi
Publication date: 01-07-2012
Publisher: Springer Japan
Published in: Surgery Today / Issue 7/2012
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-011-0105-5

At a glance: The STEP trials

Springer Medicine

The effects of the early administration of sivelestat sodium, a selective neutrophil elastase inhibitor, on the postoperative course after radical surgery for esophageal cancer

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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