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Published in: Surgery Today 1/2012

01-01-2012 | Original Article

The central vein access port and catheter in outpatient chemotherapy for colorectal cancer: a retrospective study of 101 patients

Authors: Hiroshi Sawayama, Naoko Hayashi, Masayuki Watanabe, Hiroshi Takamori, Toru Beppu, Hideo Baba

Published in: Surgery Today | Issue 1/2012

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Abstract

Purpose

The central venous access port (CV-port) system was examined in a series of colorectal cancer (CRC) patients.

Methods

One hundred and one CRC patients underwent chemotherapy with the 5-fluorouracil + oxaliplatin (FOLFOX) or 5-fluorouracil + irinotecan regimen. The complications of the CV-port system were retrospectively assessed.

Results

The CV-port system was placed in a total of 101 patients. The patients received a total of 1035 courses of these regimens. Eight complications occurred in the 101 patients (7.9%). The complications included three instances of catheter rupture, two thrombotic events around the catheter, and three infections at the site of the port or catheter. The complications were identified after a median of nine courses (range 6–16) and 135 days after the placement of the CV-port system. Sixty-six of the 101 patients switched their regimen from FOLFOX to another regimen, and 4 of these 66 patients (6.1%) experienced complications associated with the CV-port system. There were 25 subjects who were admitted to the hospital emergency wing during the chemotherapeutic regimens, and 4 of these patients (16%) had complications associated with the CV-port system.

Conclusions

The complications of the CV-port system occurred at a defined rate, therefore the early diagnosis and the appropriate treatment to address these complications is crucial.
Literature
1.
go back to reference Niederhuber JE, Ensminger W, Gyves JW, Liepman M, Doan K, Cozzi E. Totally implanted venous and arterial access system to replace external catheters in cancer treatment. Surgery. 1982;92:706–12.PubMed Niederhuber JE, Ensminger W, Gyves JW, Liepman M, Doan K, Cozzi E. Totally implanted venous and arterial access system to replace external catheters in cancer treatment. Surgery. 1982;92:706–12.PubMed
2.
go back to reference Torramade JR, Cienfuegos JA, Hernandez JL, Pardo F, Benito C, Gonzalez J, et al. The complications of central venous access systems: a study of 218 patients. Eur J Surg. 1993;159:323–7.PubMed Torramade JR, Cienfuegos JA, Hernandez JL, Pardo F, Benito C, Gonzalez J, et al. The complications of central venous access systems: a study of 218 patients. Eur J Surg. 1993;159:323–7.PubMed
3.
go back to reference Konno H, Yamamoto M, Ohta M. Recent concepts of antiangiogenic therapy. Surg Today. 2010;40:494–500.PubMedCrossRef Konno H, Yamamoto M, Ohta M. Recent concepts of antiangiogenic therapy. Surg Today. 2010;40:494–500.PubMedCrossRef
4.
go back to reference Cassidy J, Clarke S, Diaz-Rubio E, Scheithauer W, Figer A, Wong R, et al. Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer. J Clin Oncol. 2008;26:2006–12.PubMedCrossRef Cassidy J, Clarke S, Diaz-Rubio E, Scheithauer W, Figer A, Wong R, et al. Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer. J Clin Oncol. 2008;26:2006–12.PubMedCrossRef
5.
go back to reference Tsunoda A, Yasuda N, Nakao K, Narita K, Watanabe M, Matsui N, et al. Phase II study of S-1 combined with irinotecan (CPT-11) in patients with advanced colorectal cancer. Oncology. 2009;77:192–6.PubMedCrossRef Tsunoda A, Yasuda N, Nakao K, Narita K, Watanabe M, Matsui N, et al. Phase II study of S-1 combined with irinotecan (CPT-11) in patients with advanced colorectal cancer. Oncology. 2009;77:192–6.PubMedCrossRef
6.
go back to reference Ishida H, Miyake Y, Fukunaga M, Watanabe Y, Kato T, Takemoto H, et al. A feasibility study of UFT/LV and irinotecan (TEGAFIRI) in advanced or metastatic colorectal cancer: Osaka Gastrointestinal Cancer Chemotherapy Study Group (OGSG) PROG 0304. Jpn J Clin Oncol. 2009;39:601–5.PubMedCrossRef Ishida H, Miyake Y, Fukunaga M, Watanabe Y, Kato T, Takemoto H, et al. A feasibility study of UFT/LV and irinotecan (TEGAFIRI) in advanced or metastatic colorectal cancer: Osaka Gastrointestinal Cancer Chemotherapy Study Group (OGSG) PROG 0304. Jpn J Clin Oncol. 2009;39:601–5.PubMedCrossRef
7.
go back to reference Biffi R, de Braud F, Orsi F, Pozzi S, Mauri S, Goldhirsch A, et al. Totally implantable central venous access ports for long-term chemotherapy. A prospective study analyzing complications and costs of 333 devices with a minimum follow-up of 180 days. Ann Oncol. 1998;9:767–73.PubMedCrossRef Biffi R, de Braud F, Orsi F, Pozzi S, Mauri S, Goldhirsch A, et al. Totally implantable central venous access ports for long-term chemotherapy. A prospective study analyzing complications and costs of 333 devices with a minimum follow-up of 180 days. Ann Oncol. 1998;9:767–73.PubMedCrossRef
8.
go back to reference Charvat J, Linke Z, Horaekova M, Prausova J. Implantation of central venous ports with catheter insertion via the right internal jugular vein in oncology patients: single center experience. Support Care Cancer. 2006;14:1162–5.PubMedCrossRef Charvat J, Linke Z, Horaekova M, Prausova J. Implantation of central venous ports with catheter insertion via the right internal jugular vein in oncology patients: single center experience. Support Care Cancer. 2006;14:1162–5.PubMedCrossRef
9.
go back to reference Yip D, Funaki B. Subcutaneous chest ports via the internal jugular vein. A retrospective study of 117 oncology patients. Acta Radiol. 2002;43:371–5.PubMedCrossRef Yip D, Funaki B. Subcutaneous chest ports via the internal jugular vein. A retrospective study of 117 oncology patients. Acta Radiol. 2002;43:371–5.PubMedCrossRef
10.
go back to reference Funaki B, Szymski GX, Hackworth CA, Rosenblum JD, Burke R, Chang T, et al. Radiologic placement of subcutaneous infusion chest ports for long-term central venous access. AJR Am J Roentgenol. 1997;169:1431–4.PubMedCrossRef Funaki B, Szymski GX, Hackworth CA, Rosenblum JD, Burke R, Chang T, et al. Radiologic placement of subcutaneous infusion chest ports for long-term central venous access. AJR Am J Roentgenol. 1997;169:1431–4.PubMedCrossRef
11.
go back to reference Hinke DH, Zandt-Stastny DA, Goodman LR, Quebbeman EJ, Krzywda EA, Andris DA. Pinch-off syndrome: a complication of implantable subclavian venous access devices. Radiology. 1990;177:353–6.PubMed Hinke DH, Zandt-Stastny DA, Goodman LR, Quebbeman EJ, Krzywda EA, Andris DA. Pinch-off syndrome: a complication of implantable subclavian venous access devices. Radiology. 1990;177:353–6.PubMed
12.
go back to reference Andris DA, Krzywda EA, Schulte W, Ausman R, Quebbeman EJ. Pinch-off syndrome: a rare etiology for central venous catheter occlusion. JPEN J Parenter Enter Nutr. 1994;18:531–3.CrossRef Andris DA, Krzywda EA, Schulte W, Ausman R, Quebbeman EJ. Pinch-off syndrome: a rare etiology for central venous catheter occlusion. JPEN J Parenter Enter Nutr. 1994;18:531–3.CrossRef
13.
go back to reference Kawamura J, Nagayama S, Nomura A, Itami A, Okabe H, Sato S, et al. Long-term outcomes of peripheral arm ports implanted in patients with colorectal cancer. Int J Clin Oncol. 2008;13:349–54.PubMedCrossRef Kawamura J, Nagayama S, Nomura A, Itami A, Okabe H, Sato S, et al. Long-term outcomes of peripheral arm ports implanted in patients with colorectal cancer. Int J Clin Oncol. 2008;13:349–54.PubMedCrossRef
14.
go back to reference Fazeny-Dorner B, Wenzel C, Berzlanovich A, Sunder-Plassmann G, Greinix H, Marosi C, et al. Central venous catheter pinch-off and fracture: recognition, prevention and management. Bone Marrow Transplant. 2003;31:927–30.PubMedCrossRef Fazeny-Dorner B, Wenzel C, Berzlanovich A, Sunder-Plassmann G, Greinix H, Marosi C, et al. Central venous catheter pinch-off and fracture: recognition, prevention and management. Bone Marrow Transplant. 2003;31:927–30.PubMedCrossRef
15.
go back to reference De Cicco M, Matovic M, Balestreri L, Panarello G, Fantin D, Morassut S, et al. Central venous thrombosis: an early and frequent complication in cancer patients bearing long-term silastic catheter. A prospective study. Thromb Res. 1997;86:101–13.PubMedCrossRef De Cicco M, Matovic M, Balestreri L, Panarello G, Fantin D, Morassut S, et al. Central venous thrombosis: an early and frequent complication in cancer patients bearing long-term silastic catheter. A prospective study. Thromb Res. 1997;86:101–13.PubMedCrossRef
16.
go back to reference Cortelezzi A, Moia M, Falanga A, Pogliani EM, Agnelli G, Bonizzoni E, et al. Incidence of thrombotic complications in patients with haematological malignancies with central venous catheters: a prospective multicentre study. Br J Haematol. 2005;129:811–7.PubMedCrossRef Cortelezzi A, Moia M, Falanga A, Pogliani EM, Agnelli G, Bonizzoni E, et al. Incidence of thrombotic complications in patients with haematological malignancies with central venous catheters: a prospective multicentre study. Br J Haematol. 2005;129:811–7.PubMedCrossRef
17.
go back to reference Verso M, Agnelli G, Bertoglio S, Di Somma FC, Paoletti F, Ageno W, et al. Enoxaparin for the prevention of venous thromboembolism associated with central vein catheter: a double-blind, placebo-controlled, randomized study in cancer patients. J Clin Oncol. 2005;23:4057–62.PubMedCrossRef Verso M, Agnelli G, Bertoglio S, Di Somma FC, Paoletti F, Ageno W, et al. Enoxaparin for the prevention of venous thromboembolism associated with central vein catheter: a double-blind, placebo-controlled, randomized study in cancer patients. J Clin Oncol. 2005;23:4057–62.PubMedCrossRef
18.
go back to reference Couban S, Goodyear M, Burnell M, Dolan S, Wasi P, Barnes D, et al. Randomized placebo-controlled study of low-dose warfarin for the prevention of central venous catheter-associated thrombosis in patients with cancer. J Clin Oncol. 2005;23:4063–9.PubMedCrossRef Couban S, Goodyear M, Burnell M, Dolan S, Wasi P, Barnes D, et al. Randomized placebo-controlled study of low-dose warfarin for the prevention of central venous catheter-associated thrombosis in patients with cancer. J Clin Oncol. 2005;23:4063–9.PubMedCrossRef
19.
go back to reference Karthaus M, Kretzschmar A, Kroning H, Biakhov M, Irwin D, Marschner N, et al. Dalteparin for prevention of catheter-related complications in cancer patients with central venous catheters: final results of a double-blind, placebo-controlled phase III trial. Ann Oncol. 2006;17:289–96.PubMedCrossRef Karthaus M, Kretzschmar A, Kroning H, Biakhov M, Irwin D, Marschner N, et al. Dalteparin for prevention of catheter-related complications in cancer patients with central venous catheters: final results of a double-blind, placebo-controlled phase III trial. Ann Oncol. 2006;17:289–96.PubMedCrossRef
20.
go back to reference Vescia S, Baumgartner AK, Jacobs VR, Kiechle-Bahat M, Rody A, Loibl S, et al. Management of venous port systems in oncology: a review of current evidence. Ann Oncol. 2008;19:9–15.PubMedCrossRef Vescia S, Baumgartner AK, Jacobs VR, Kiechle-Bahat M, Rody A, Loibl S, et al. Management of venous port systems in oncology: a review of current evidence. Ann Oncol. 2008;19:9–15.PubMedCrossRef
21.
go back to reference Bouza E, Burillo A, Munoz P. Catheter-related infections: diagnosis and intravascular treatment. Clin Microbiol Infect. 2002;8:265–74.PubMedCrossRef Bouza E, Burillo A, Munoz P. Catheter-related infections: diagnosis and intravascular treatment. Clin Microbiol Infect. 2002;8:265–74.PubMedCrossRef
22.
go back to reference Ouriel K. Preventing complications of central venous catheterization. N Engl J Med. 2003;348:2684–6 (author reply 2684–6). Ouriel K. Preventing complications of central venous catheterization. N Engl J Med. 2003;348:2684–6 (author reply 2684–6).
23.
go back to reference Kovacevich DS, Papke LF. Guidelines for the prevention of intravascular catheter-related infections: Centers for Disease Control and Prevention. Nutr Clin Pract. 2003;18:95–6.PubMedCrossRef Kovacevich DS, Papke LF. Guidelines for the prevention of intravascular catheter-related infections: Centers for Disease Control and Prevention. Nutr Clin Pract. 2003;18:95–6.PubMedCrossRef
Metadata
Title
The central vein access port and catheter in outpatient chemotherapy for colorectal cancer: a retrospective study of 101 patients
Authors
Hiroshi Sawayama
Naoko Hayashi
Masayuki Watanabe
Hiroshi Takamori
Toru Beppu
Hideo Baba
Publication date
01-01-2012
Publisher
Springer-Verlag
Published in
Surgery Today / Issue 1/2012
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-011-0016-5

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