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European Journal of Orthopaedic Surgery & Traumatology

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01-07-2018 | Original Article • LOWER LINB - FRACTURES

Role of isolated percutaneous autologous platelet concentrate in delayed union of long bones

Authors: Gipson Samuel, Jagdish Menon, Sreenivas Thimmaiah, Gayadhar Behera

Published in: European Journal of Orthopaedic Surgery & Traumatology | Issue 5/2018

Abstract

Purpose

The objective of this study is to evaluate the efficacy of percutaneous platelet concentrate (PC) injection in increasing the chances of attaining union in delayed union of long bones and to know whether the time taken for union decreases with use of PC.

Methods

Forty delayed unions (15–30 weeks old) were randomized into a study group in which autologous PC prepared by blood bank centrifuge was percutaneously injected at the fracture site under image intensifier after activation with 10% calcium gluconate and a control group where patients were observed over time. Follow-up was every 6 weeks till fracture union. At each follow-up visit clinical and radiological parameters of union were assessed.

Results

Percentage union was 78% (18/23) in PC group and 59% (10/17) in control group, respectively (p = 0.296). The mean time to fracture union treated with PC (15.33 ± 9.91 weeks) was not different from the control group (13.10 ± 7.21 weeks; p = 0.540). In the PC group union is seen in 12 weeks after PC injection in 60 per cent of the cases.

Conclusion

Isolated percutaneous PC injection increases union rates in delayed union of long bones. The results were, however, not statistically significant but show high positive association. Further studies are required to recommend routine use of PC injection.

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Title: Role of isolated percutaneous autologous platelet concentrate in delayed union of long bones
Authors: Gipson Samuel
Jagdish Menon
Sreenivas Thimmaiah
Gayadhar Behera
Publication date: 01-07-2018
Publisher: Springer Paris
Published in: European Journal of Orthopaedic Surgery & Traumatology / Issue 5/2018
Print ISSN: 1633-8065
Electronic ISSN: 1432-1068
DOI: https://doi.org/10.1007/s00590-017-2077-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Role of isolated percutaneous autologous platelet concentrate in delayed union of long bones

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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