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European Journal of Orthopaedic Surgery & Traumatology

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01-05-2017 | General Review • HIP - ARTHROPLASTY

Silver-coated megaprostheses: review of the literature

Authors: Tom Schmidt-Braekling, Arne Streitbuerger, Georg Gosheger, Friedrich Boettner, Markus Nottrott, Helmut Ahrens, Ralf Dieckmann, Wiebke Guder, Dimosthenis Andreou, Gregor Hauschild, Burkhard Moellenbeck, Wenzel Waldstein, Jendrik Hardes

Published in: European Journal of Orthopaedic Surgery & Traumatology | Issue 4/2017

Abstract

Periprosthetic infection remains one of the most serious complications following megaendoprostheses. Despite a large number of preventive measures that have been introduced in recent years, it has not been possible to further reduce the rate of periprosthetic infection. With regard to metallic modification of implants, silver in particular has been regarded as highly promising, since silver particles combine a high degree of antimicrobial activity with a low level of human toxicity. This review provides an overview of the history of the use of silver as an antimicrobial agent, its mechanism of action, and its clinical application in the field of megaendoprosthetics. The benefits of silver-coated prostheses could not be confirmed until now. However, a large number of retrospective studies suggest that the rate of periprosthetic infections could be reduced by using silver-coated megaprostheses.

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Title: Silver-coated megaprostheses: review of the literature
Authors: Tom Schmidt-Braekling
Arne Streitbuerger
Georg Gosheger
Friedrich Boettner
Markus Nottrott
Helmut Ahrens
Ralf Dieckmann
Wiebke Guder
Dimosthenis Andreou
Gregor Hauschild
Burkhard Moellenbeck
Wenzel Waldstein
Jendrik Hardes
Publication date: 01-05-2017
Publisher: Springer Paris
Published in: European Journal of Orthopaedic Surgery & Traumatology / Issue 4/2017
Print ISSN: 1633-8065
Electronic ISSN: 1432-1068
DOI: https://doi.org/10.1007/s00590-017-1933-9

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