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European Journal of Orthopaedic Surgery & Traumatology

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01-10-2017 | Original Article • HIP - ARTHROPLASTY

Tranexamic acid versus fibrin sealant in primary total hip replacement: a comparative study

Authors: Aatif Mahmood, Seif Sawalha, Aaron Borbora, Gunasekaran Kumar, Viju Peter

Published in: European Journal of Orthopaedic Surgery & Traumatology | Issue 7/2017

Abstract

Background

The effectiveness of intravenous tranexamic acid (TA) in reducing blood loss and transfusion requirements during total hip replacement (THR) is well recognised. The aim of this study was to assess the effectiveness of a fibrin sealant in comparison to intravenous TA and a control group.

Patients and methods

We prospectively studied 273 patients with primary hip osteoarthritis who underwent a THR between February 2012 and September 2013. The first 73 patients acted as the control group. The next 100 consecutive patients received fibrin sealant spray, and the last 100 patients received 1 g TA on induction.

Results

The demographic characteristics, surgical time, surgeon grade, anaesthetic type and pre-operative haemoglobin of the three groups were comparable. Both fibrin sealant and intravenous TA were effective in reducing blood loss during THR (15%, p = 0.04 and 22.5%, p = 0.01, respectively), when compared to the control group. However, neither treatment was found to be superior to the other in preventing blood loss p = 0.39. Tranexamic acid was superior to fibrin sealant in decreasing allogeneic transfusion requirements (0 vs. 10%, p = 0.05). There was no significant difference between the groups with regard to proportion of patients with wound leaking problems.

Conclusion

Both fibrin sealant and intravenous tranexamic acid were effective in reducing blood loss. However, tranexamic acid use reduced post-operative transfusion requirements.

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Title: Tranexamic acid versus fibrin sealant in primary total hip replacement: a comparative study
Authors: Aatif Mahmood
Seif Sawalha
Aaron Borbora
Gunasekaran Kumar
Viju Peter
Publication date: 01-10-2017
Publisher: Springer Paris
Published in: European Journal of Orthopaedic Surgery & Traumatology / Issue 7/2017
Print ISSN: 1633-8065
Electronic ISSN: 1432-1068
DOI: https://doi.org/10.1007/s00590-017-1910-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Tranexamic acid versus fibrin sealant in primary total hip replacement: a comparative study

Abstract

Background

Patients and methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Patients and methods

Results

Conclusion

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