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Published in: European Journal of Orthopaedic Surgery & Traumatology 2/2016

01-02-2016 | Original Article • KNEE - INFECTION

Prevalence of asymptomatic bacteriuria in knee arthroplasty patients and subsequent risk of prosthesis infection

Authors: David Martínez-Vélez, Enrique González-Fernández, Jaime Esteban, José Cordero-Ampuero

Published in: European Journal of Orthopaedic Surgery & Traumatology | Issue 2/2016

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Abstract

Introduction

The risk of knee arthroplasty infection and appropriateness of antibiotic treatment are not clearly established in patients with preoperative asymptomatic bacteriuria. It has been the purpose to analyze the prevalence of preoperative asymptomatic bacteriuria in knee arthroplasty patients, as well as the incidence of prosthetic joint infection in those with asymptomatic bacteriuria treated and not with specific antibiotics.

Patients and methods

This prospective study included 215 consecutive knee arthroplasty patients (73 ± 6 years, 168 females) with neither urinary symptoms nor perioperative urethral catheterization. A “clean-catch” urinalysis was obtained from all patients before surgery and an urine culture if urinalysis was abnormal. Asymptomatic bacteriuria was diagnosed if >100,000 colony-forming units/ml were cultured. Patients were treated (Group A) or not (Group B) with additional specific antibiotics for urine bacteria according to surgeon criteria. Minimum follow-up reached 48 months. No patient was lost to follow-up.

Results

Asymptomatic bacteriuria was diagnosed in 11/215 patients (5.1 %) (11/11 females), and four of these 11 were treated with specific antibiotics (Group A). Only one patient in Group A suffered a prosthesis infection along the first 3 months (1/125, 0.5 %), but bacteria cultured from the wound were absolutely different to those in urine culture. No patient in Group B suffered a prosthesis infection.

Conclusions

Asymptomatic bacteriuria presents a low prevalence. We have not found any case of arthroplasty infection from urinary focus in patients with asymptomatic bacteriuria whether they received or not specific antibiotics.
Literature
1.
go back to reference Glynn MK, Sheehan JM (1984) The significance of asymptomatic bacteriuria in patients undergoing hip/knee arthroplasty. Clin Orthop Relat Res 185:151–154PubMed Glynn MK, Sheehan JM (1984) The significance of asymptomatic bacteriuria in patients undergoing hip/knee arthroplasty. Clin Orthop Relat Res 185:151–154PubMed
2.
go back to reference Sousa R, Muñoz-Mahamud E, Quayle J, Dias da Costa L, Casals C, Scott P, Leite P, Vilanova P, García S, Ramos MH, Dias J, Soriano A, Guyot A (2014) Is asymptomatic bacteriuria a risk factor for prosthetic joint infection? Clin Infect Dis 59:41–47. doi:10.1093/cid/ciu235 PubMedCentralCrossRefPubMed Sousa R, Muñoz-Mahamud E, Quayle J, Dias da Costa L, Casals C, Scott P, Leite P, Vilanova P, García S, Ramos MH, Dias J, Soriano A, Guyot A (2014) Is asymptomatic bacteriuria a risk factor for prosthetic joint infection? Clin Infect Dis 59:41–47. doi:10.​1093/​cid/​ciu235 PubMedCentralCrossRefPubMed
5.
go back to reference David TS, Vrahas MS (2000) Perioperative lower urinary tract infections and deep sepsis in patients undergoing total joint arthroplasty. J Am Acad Orthop Surg 8:66–74PubMed David TS, Vrahas MS (2000) Perioperative lower urinary tract infections and deep sepsis in patients undergoing total joint arthroplasty. J Am Acad Orthop Surg 8:66–74PubMed
6.
go back to reference Otermin I, Rivero M, Hidalgo A (2009) Is it necessary to delay or to put off surgery in the case of possible asymptomatic bacteriuria and orthopaedic surgery with implants? Enferm Infecc Microbiol Clin 27:252–253CrossRefPubMed Otermin I, Rivero M, Hidalgo A (2009) Is it necessary to delay or to put off surgery in the case of possible asymptomatic bacteriuria and orthopaedic surgery with implants? Enferm Infecc Microbiol Clin 27:252–253CrossRefPubMed
7.
go back to reference Rajamanickam A, Noor S, Usmani A (2007) Should an asymptomatic patient with an abnormal urinalysis (bacteriuria or pyuria) be treated with antibiotics prior to major joint replacement surgery? Cleve Clin J Med 74(suppl 1):S17–S18CrossRefPubMed Rajamanickam A, Noor S, Usmani A (2007) Should an asymptomatic patient with an abnormal urinalysis (bacteriuria or pyuria) be treated with antibiotics prior to major joint replacement surgery? Cleve Clin J Med 74(suppl 1):S17–S18CrossRefPubMed
8.
go back to reference Nicolle LE (2003) Asymptomatic bacteriuria: when to screen and when to treat. Infect Dis Clin North Am 17:367–394CrossRefPubMed Nicolle LE (2003) Asymptomatic bacteriuria: when to screen and when to treat. Infect Dis Clin North Am 17:367–394CrossRefPubMed
9.
go back to reference Nicolle LE, Bradley S, Colgan R, Rice JC, Schaeffer A, Hooton TM (2005) Infectious diseases society of America guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults. Clin Infect Dis 40:1556CrossRef Nicolle LE, Bradley S, Colgan R, Rice JC, Schaeffer A, Hooton TM (2005) Infectious diseases society of America guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults. Clin Infect Dis 40:1556CrossRef
10.
go back to reference Gleckman R, Esposito A, Crowley M, Natsios GA (1979) Reliability of a single urine culture in establishing diagnosis of asymptomatic bacteriuria in adult males. J Clin Microbiol 9:596–597PubMedCentralPubMed Gleckman R, Esposito A, Crowley M, Natsios GA (1979) Reliability of a single urine culture in establishing diagnosis of asymptomatic bacteriuria in adult males. J Clin Microbiol 9:596–597PubMedCentralPubMed
11.
go back to reference Juthani-Mehta M (2007) Asymptomatic bacteriuria and urinary tract infection in older adults. Clin Geriatr Med 23:585–594CrossRefPubMed Juthani-Mehta M (2007) Asymptomatic bacteriuria and urinary tract infection in older adults. Clin Geriatr Med 23:585–594CrossRefPubMed
12.
go back to reference Parvizi J, Morrison WB, Alavi A (2009) Diagnostic imaging of periprosthetic joint infections. In: Cierny G III, McLaren AC, Wongworawat MD (eds) Orthopaedic Knowledge update: musculoskeletal infection. American Academy of Orthopaedic Surgeons, Rosemont, pp 67–72 Parvizi J, Morrison WB, Alavi A (2009) Diagnostic imaging of periprosthetic joint infections. In: Cierny G III, McLaren AC, Wongworawat MD (eds) Orthopaedic Knowledge update: musculoskeletal infection. American Academy of Orthopaedic Surgeons, Rosemont, pp 67–72
13.
go back to reference Parvizi J, Zmistowski B, Berbari EF, Bauer TW, Springer BD, Della Valle CJ, Garvin KL, Mont MA, Wongworawat MD, Zalavras CG (2011) New definition for periprosthetic joint infection: from the Workgroup of the Musculoskeletal Infection Society. Clin Orthop Relat Res 469:2992–2994PubMedCentralCrossRefPubMed Parvizi J, Zmistowski B, Berbari EF, Bauer TW, Springer BD, Della Valle CJ, Garvin KL, Mont MA, Wongworawat MD, Zalavras CG (2011) New definition for periprosthetic joint infection: from the Workgroup of the Musculoskeletal Infection Society. Clin Orthop Relat Res 469:2992–2994PubMedCentralCrossRefPubMed
14.
go back to reference Bengtsson C, Bengtsson U, Björkelund C, Lincoln K, Sigurdsson JA (1998) Bacteriuria in a population sample of women: 24-year follow-up study. Results from the prospective population-based study of women in Gothenburg. Sweden. Scand J Urol Nephrol 32:284–289CrossRefPubMed Bengtsson C, Bengtsson U, Björkelund C, Lincoln K, Sigurdsson JA (1998) Bacteriuria in a population sample of women: 24-year follow-up study. Results from the prospective population-based study of women in Gothenburg. Sweden. Scand J Urol Nephrol 32:284–289CrossRefPubMed
15.
go back to reference Hooton TM, Scholes D, Stapleton AE, Roberts PL, Winter C, Gupta K, Samadpour M, Stamm WE (2000) A prospective study of asymptomatic bacteriuria in sexually active young women. N Engl J Med 343:992–997CrossRefPubMed Hooton TM, Scholes D, Stapleton AE, Roberts PL, Winter C, Gupta K, Samadpour M, Stamm WE (2000) A prospective study of asymptomatic bacteriuria in sexually active young women. N Engl J Med 343:992–997CrossRefPubMed
16.
go back to reference Colgan R, Nicolle LE, McGlone A, Hooton TM (2006) Asymptomatic bacteriuria in adults. Am Fam Physician 74:985–990PubMed Colgan R, Nicolle LE, McGlone A, Hooton TM (2006) Asymptomatic bacteriuria in adults. Am Fam Physician 74:985–990PubMed
17.
go back to reference Ritter MA, Fechtman RW (1987) Urinary tract sequelae: possible influence on joint infections following total joint replacement. Orthopedics 10:467–469PubMed Ritter MA, Fechtman RW (1987) Urinary tract sequelae: possible influence on joint infections following total joint replacement. Orthopedics 10:467–469PubMed
18.
go back to reference Wymenga AB, van Horn JR, Theeuwes A, Muytjens HL, Slooff TJ (1992) Perioperative factors associated with septic arthritis after arthroplasty. Prospective multicenter study of 362 knee and 2651 hip operations. Acta Orthop Scand 63:665–671PubMed Wymenga AB, van Horn JR, Theeuwes A, Muytjens HL, Slooff TJ (1992) Perioperative factors associated with septic arthritis after arthroplasty. Prospective multicenter study of 362 knee and 2651 hip operations. Acta Orthop Scand 63:665–671PubMed
19.
go back to reference Ainscow DA, Denham RA (1984) The risk of hematogenous infection in total joint replacements. J Bone Joint Surg Br 66-B:580–582 Ainscow DA, Denham RA (1984) The risk of hematogenous infection in total joint replacements. J Bone Joint Surg Br 66-B:580–582
20.
go back to reference Jahoda D, Nyc O, Simsa J, Kucera E, Hanek P, Chrz P, Pokorný D, Tawa N, Landor I, Sosna A (2008) Late hematogenus infection of prosthetic Joint. Acta Chir Orthop Traumatol Cech 75:88–92PubMed Jahoda D, Nyc O, Simsa J, Kucera E, Hanek P, Chrz P, Pokorný D, Tawa N, Landor I, Sosna A (2008) Late hematogenus infection of prosthetic Joint. Acta Chir Orthop Traumatol Cech 75:88–92PubMed
24.
go back to reference Maderazo E, Judson S, Pasternak H (1988) Late infections of total joint prostheses. A review and recommendations for prevention. Clin Orthop Relat Res 229:131–142PubMed Maderazo E, Judson S, Pasternak H (1988) Late infections of total joint prostheses. A review and recommendations for prevention. Clin Orthop Relat Res 229:131–142PubMed
Metadata
Title
Prevalence of asymptomatic bacteriuria in knee arthroplasty patients and subsequent risk of prosthesis infection
Authors
David Martínez-Vélez
Enrique González-Fernández
Jaime Esteban
José Cordero-Ampuero
Publication date
01-02-2016
Publisher
Springer Paris
Published in
European Journal of Orthopaedic Surgery & Traumatology / Issue 2/2016
Print ISSN: 1633-8065
Electronic ISSN: 1432-1068
DOI
https://doi.org/10.1007/s00590-015-1720-4

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