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Published in: European Spine Journal 9/2019

01-09-2019 | Hypotension | Original Article

The incidence of myocardial infarction after lumbar spine surgery

Authors: Brett Harwin, Blake Formanek, Mark Spoonamore, Djani Robertson, Zorica Buser, Jeffrey C. Wang

Published in: European Spine Journal | Issue 9/2019

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Abstract

Purpose

As the population continues to age, the number of lumbar spine surgeries continues to increase. While there are many complications associated with lumbar surgeries, a myocardial infarction (MI) is a particularly devastating one. This complication is of considerable importance with mortality rates of postoperative MI documented between 26.5 and 70%. This study aimed to determine the relationship between lumbar surgeries, preoperative diagnoses (risk factors), and myocardial infarction.

Methods

Data from the Humana database (PearlDiver) were analyzed from 2007 to 2016. Patients undergoing lumbar spine surgeries were identified and stratified based on procedural approach, patient demographics, and preoperative risk factors. Each group was analyzed to determine the incidence and relative risk. Chi-square analysis was used to determine the significance.

Results

A total of 105,505 patients who fit inclusion criteria were identified in the PearlDiver database between 2007 and 2016. A total of 644 patients (0.63%) experienced a postoperative myocardial infarction within 30 days of surgery. Patients undergoing fusion and non-fusion procedures showed significantly different rates of postoperative myocardial infarction (0.08% vs. 0.05%, p < 0.01). Male patients, older patients, and patients with a Charlson comorbidity index > 3 showed a considerable increase in incidence (p < 0.01). Furthermore, patients with preoperative risk factors (high cholesterol, obesity, depression, congestive heart failure, hypertension, and hypotension) exhibited risk ratios from 0.01 to 1.85 (p < 0.01).

Conclusion

Preoperative risk factors, patient demographics, and procedure type had a significant effect on the incidence of postoperative myocardial infarction.

Graphic abstract

These slides can be retrieved under Electronic Supplementary Material.
Appendix
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Literature
1.
go back to reference Cholewicki J, McGill S (1996) Mechanical stability of the in vivo lumbar spine: implications for injury and chronic low back pain. Clin Biomech 11(1):1–15CrossRef Cholewicki J, McGill S (1996) Mechanical stability of the in vivo lumbar spine: implications for injury and chronic low back pain. Clin Biomech 11(1):1–15CrossRef
2.
go back to reference Warwick Dn, Berkson Mh, Nachemson AL, Schultz AB (1979) Mechanical properties of human lumbar spine motion segments—part I: responses in flexion, extension, lateral bending, and torsion. J Biomech Eng 101(1):46–52CrossRef Warwick Dn, Berkson Mh, Nachemson AL, Schultz AB (1979) Mechanical properties of human lumbar spine motion segments—part I: responses in flexion, extension, lateral bending, and torsion. J Biomech Eng 101(1):46–52CrossRef
3.
go back to reference Dimick JB, Cowan JA, Wainess R, Upchurch GR Jr, Chandler WF, La Marca F (2006) Changes in utilization of spinal fusion in the United States. Neurosurg Online 59(1):15–20CrossRef Dimick JB, Cowan JA, Wainess R, Upchurch GR Jr, Chandler WF, La Marca F (2006) Changes in utilization of spinal fusion in the United States. Neurosurg Online 59(1):15–20CrossRef
4.
go back to reference Ahmadinia Kasra, Patel Alpesh A, Oglesby Matthew, Singh Kern, Fineberg Steven J, Patel Alpesh A (2013) Incidence and mortality of cardiac events in lumbar spine surgery. Spine 38(16):1422–1429CrossRefPubMed Ahmadinia Kasra, Patel Alpesh A, Oglesby Matthew, Singh Kern, Fineberg Steven J, Patel Alpesh A (2013) Incidence and mortality of cardiac events in lumbar spine surgery. Spine 38(16):1422–1429CrossRefPubMed
5.
go back to reference Lee MJ, Konodi MA, Cizik AM, Bransford RJ, Bellabarba C, Chapman JR (2012) Risk factors for medical complication after spine surgery: a multivariate analysis of 1,591 patients. Spine J 12(3):197–206CrossRefPubMedPubMedCentral Lee MJ, Konodi MA, Cizik AM, Bransford RJ, Bellabarba C, Chapman JR (2012) Risk factors for medical complication after spine surgery: a multivariate analysis of 1,591 patients. Spine J 12(3):197–206CrossRefPubMedPubMedCentral
6.
go back to reference Faciszewski T, Jensen R, Rokey R, Berg R (2001) Cardiac risk stratification of patients with symptomatic spinal stenosis. Clin Orthop Relat Res 384:110–115CrossRef Faciszewski T, Jensen R, Rokey R, Berg R (2001) Cardiac risk stratification of patients with symptomatic spinal stenosis. Clin Orthop Relat Res 384:110–115CrossRef
7.
go back to reference Lee S-H, Jang J-S, Lee DY, Lee S-H, Jang J-S (2007) Risk factors for perioperative cardiac complications after lumbar fusion surgery. Neurol Med Chir 47(11):495–500CrossRef Lee S-H, Jang J-S, Lee DY, Lee S-H, Jang J-S (2007) Risk factors for perioperative cardiac complications after lumbar fusion surgery. Neurol Med Chir 47(11):495–500CrossRef
9.
go back to reference Thompson J, Baxter B, Allison J, Johnson F, Lee K, Park W (2003) Temporal patterns of postoperative complications. Arch Surg 138(6):596–602 (discussion 602) CrossRefPubMed Thompson J, Baxter B, Allison J, Johnson F, Lee K, Park W (2003) Temporal patterns of postoperative complications. Arch Surg 138(6):596–602 (discussion 602) CrossRefPubMed
10.
go back to reference Tarhan S, Moffitt E, Taylor W, Giuliani E (1972) Myocardial infarction after general anesthesia. Anesth Analg 56(3):455–461 Tarhan S, Moffitt E, Taylor W, Giuliani E (1972) Myocardial infarction after general anesthesia. Anesth Analg 56(3):455–461
11.
go back to reference Eagle K, Rihal K, Mickel C, Holmes M, Foster D, Gersh E (1997) Cardiac risk of noncardiac surgery: influence of coronary disease and type of surgery in 3368 operations. CASS Investigators and University of Michigan Heart Care Program. Coronary Artery Surgery Study. Circ J Am Heart Assoc 96(6):1882–1887 Eagle K, Rihal K, Mickel C, Holmes M, Foster D, Gersh E (1997) Cardiac risk of noncardiac surgery: influence of coronary disease and type of surgery in 3368 operations. CASS Investigators and University of Michigan Heart Care Program. Coronary Artery Surgery Study. Circ J Am Heart Assoc 96(6):1882–1887
12.
go back to reference Huddleston J, Gullerud R, Smither F, Larson P, Phy D, Melton M, Roger L (2012) Myocardial infarction after hip fracture repair: a population-based study. J Am Geriatr Soc 60(11):2020–2026CrossRefPubMedPubMedCentral Huddleston J, Gullerud R, Smither F, Larson P, Phy D, Melton M, Roger L (2012) Myocardial infarction after hip fracture repair: a population-based study. J Am Geriatr Soc 60(11):2020–2026CrossRefPubMedPubMedCentral
13.
go back to reference Steen P, Tinker J, Tarhan S (1978) Myocardial reinfarction after anesthesia and surgery. JAMA 239(24):2566–2570CrossRefPubMed Steen P, Tinker J, Tarhan S (1978) Myocardial reinfarction after anesthesia and surgery. JAMA 239(24):2566–2570CrossRefPubMed
14.
go back to reference Topkins M, Artusio J (1964) Myocardial infarction and surgery: a five year study. Anesth Analg 43:716–720CrossRefPubMed Topkins M, Artusio J (1964) Myocardial infarction and surgery: a five year study. Anesth Analg 43:716–720CrossRefPubMed
15.
go back to reference Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40(5):373–383CrossRefPubMed Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40(5):373–383CrossRefPubMed
16.
go back to reference Núñez E, Facila L, Bertomeu V, Llacer A, Núñez JE, Chorro FJ (2004) Prognostic value of Charlson Comorbidity Index at 30 days and 1 year after acute myocardial infarction. Revista Española De Cardiología: Publicación Oficial De La Sociedad Española De Cardiología 57(9):842–849CrossRef Núñez E, Facila L, Bertomeu V, Llacer A, Núñez JE, Chorro FJ (2004) Prognostic value of Charlson Comorbidity Index at 30 days and 1 year after acute myocardial infarction. Revista Española De Cardiología: Publicación Oficial De La Sociedad Española De Cardiología 57(9):842–849CrossRef
17.
go back to reference Kikura M, Oikawa F, Yamamoto K, Iwamoto T, Tanaka KA, Sato S, Landesberg G (2008) Myocardial infarction and cerebrovascular accident following non-cardiac surgery: differences in postoperative temporal distribution and risk factors. J Thromb Haemost 6(5):742–748CrossRefPubMed Kikura M, Oikawa F, Yamamoto K, Iwamoto T, Tanaka KA, Sato S, Landesberg G (2008) Myocardial infarction and cerebrovascular accident following non-cardiac surgery: differences in postoperative temporal distribution and risk factors. J Thromb Haemost 6(5):742–748CrossRefPubMed
18.
go back to reference Von Knorring J (1981) Postoperative myocardial infarction: a prospective study in a risk group of surgical patients. Surgery 90(1):55–60 Von Knorring J (1981) Postoperative myocardial infarction: a prospective study in a risk group of surgical patients. Surgery 90(1):55–60
19.
go back to reference de Torbal A, Boersma E, Kors JA, van Herpen G, Deckers JW, van der Kuip DA, Stricker BH, Hofman A, Witteman JC (2006) Incidence of recognized and unrecognized myocardial infarction in men and women aged 55 and older: the Rotterdam Study. Eur Heart J 27(6):729–736CrossRefPubMed de Torbal A, Boersma E, Kors JA, van Herpen G, Deckers JW, van der Kuip DA, Stricker BH, Hofman A, Witteman JC (2006) Incidence of recognized and unrecognized myocardial infarction in men and women aged 55 and older: the Rotterdam Study. Eur Heart J 27(6):729–736CrossRefPubMed
20.
go back to reference Yusuf S, Hawken S, Ôunpuu S, Dans T, Avezum A, Lanas F, McQueen M, Budaj A, Pais P, Varigos J, Lisheng L (2004) Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. The Lancet 364(9438):937–952CrossRef Yusuf S, Hawken S, Ôunpuu S, Dans T, Avezum A, Lanas F, McQueen M, Budaj A, Pais P, Varigos J, Lisheng L (2004) Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. The Lancet 364(9438):937–952CrossRef
21.
go back to reference Lewis La, Page IH, Lewis LA (1959) Lipoproteins, cholesterol and serum proteins as predictors of myocardial infarction. Circulation 20(6):1011–1027CrossRefPubMed Lewis La, Page IH, Lewis LA (1959) Lipoproteins, cholesterol and serum proteins as predictors of myocardial infarction. Circulation 20(6):1011–1027CrossRefPubMed
22.
go back to reference Medalie J, Kahn H, Neufeld H, Riss E, Goldbourt U (1973) Five-year myocardial infarction incidence. II. Association of single variables to age and birthplace. J Chronic Dis 26(6):325–349CrossRefPubMed Medalie J, Kahn H, Neufeld H, Riss E, Goldbourt U (1973) Five-year myocardial infarction incidence. II. Association of single variables to age and birthplace. J Chronic Dis 26(6):325–349CrossRefPubMed
23.
go back to reference Arrieta Mi, Leaverton Pe, Ross Ea, Schocken Douglas D, Arrieta Martha I, Leaverton Paul E, Ross Eric A (1992) Prevalence and mortality rate of congestive heart failure in the United States. J Am Coll Cardiol 20(2):301–306CrossRefPubMed Arrieta Mi, Leaverton Pe, Ross Ea, Schocken Douglas D, Arrieta Martha I, Leaverton Paul E, Ross Eric A (1992) Prevalence and mortality rate of congestive heart failure in the United States. J Am Coll Cardiol 20(2):301–306CrossRefPubMed
24.
go back to reference Barone JE, Bull MB, Cussatti EH, Miller KD, Tucker JB (2002) Review of a large clinical series: perioperative myocardial infarction in low-risk patients undergoing noncardiac surgery is associated with intraoperative hypotension. J Intensive Care Med 17(5):250–255CrossRef Barone JE, Bull MB, Cussatti EH, Miller KD, Tucker JB (2002) Review of a large clinical series: perioperative myocardial infarction in low-risk patients undergoing noncardiac surgery is associated with intraoperative hypotension. J Intensive Care Med 17(5):250–255CrossRef
25.
go back to reference Thorgeirsson G et al (1995) Unrecognized myocardial infarction: epidemiology, clinical characteristics, and the prognostic role of angina pectoris: the Reykjavik Study. Ann Intern Med 122(2):96–102CrossRefPubMed Thorgeirsson G et al (1995) Unrecognized myocardial infarction: epidemiology, clinical characteristics, and the prognostic role of angina pectoris: the Reykjavik Study. Ann Intern Med 122(2):96–102CrossRefPubMed
Metadata
Title
The incidence of myocardial infarction after lumbar spine surgery
Authors
Brett Harwin
Blake Formanek
Mark Spoonamore
Djani Robertson
Zorica Buser
Jeffrey C. Wang
Publication date
01-09-2019
Publisher
Springer Berlin Heidelberg
Published in
European Spine Journal / Issue 9/2019
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI
https://doi.org/10.1007/s00586-019-06072-4

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