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01-12-2017 | Original Article

Modic changes in the adjacent vertebrae due to disc material infection with Propionibacterium acnes in patients with lumbar disc herniation

Authors: Javad Aghazadeh, Firooz Salehpour, Ehsan Ziaeii, Naghme Javanshir, Afshin Samadi, Javid sadeghi, Farhad Mirzaei, Seyed Ahmad Naseri Alavi

Published in: European Spine Journal | Issue 12/2017

Abstract

Introduction

Modic changes (MCs) in vertebral bones are induced by two mechanisms of mechanical factors and infection. As Propionibacterium acnes (P. acnes) have been reported to be associated with LBP. The aim of this study is to evaluate the MCs in patients with disc herniation and positive for P. acnes.

Methods and material

A total of 120 patients with disc herniation surgery were enrolled into the study. The samples were excised during discectomy and then cultured in both anaerobic and aerobic incubations. Gram staining was employed for investigation of all colonies. The cultured P. acnes were detected by 16S rRNA-based polymerase chain reaction (PCR). MCs of baseline MRI were evaluated.

Results

In this study, 120 subjects (69 male and 51 female) with mean age of 43.15 ± 12.62 years were investigated. Sixty disc samples and eight muscle samples were positive for microorganisms. Moreover, 16S rDNA gene was identified in 46 (38.3%) disc samples. Moreover, 36/46 patients with P. acnes in their sample had MCs.

Conclusion

According to the results and presence of 36/46 MCs in patients with lumbar disc herniation, positive for P. acnes suggests that P. acnes can lead to edema on the vertebrae endplates near to infected area.

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Title: Modic changes in the adjacent vertebrae due to disc material infection with Propionibacterium acnes in patients with lumbar disc herniation
Authors: Javad Aghazadeh
Firooz Salehpour
Ehsan Ziaeii
Naghme Javanshir
Afshin Samadi
Javid sadeghi
Farhad Mirzaei
Seyed Ahmad Naseri Alavi
Publication date: 01-12-2017
Publisher: Springer Berlin Heidelberg
Published in: European Spine Journal / Issue 12/2017
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-016-4887-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Modic changes in the adjacent vertebrae due to disc material infection with Propionibacterium acnes in patients with lumbar disc herniation

Abstract

Introduction

Methods and material

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Methods and material

Results

Conclusion

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