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European Spine Journal

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01-05-2016 | Case Report

Carbon-ion radiotherapy of spinal osteosarcoma with long-term follow

Authors: Wei Zhang, Masato Tanaka, Yoshihisa Sugimoto, Tomoyuki Takigawa, Toshifumi Ozaki

Published in: European Spine Journal | Special Issue 1/2016

Abstract

Purpose

Primary spinal osteosarcoma is quite rare, and the 5-year survival rate is very low. Because of its rarity, successful treatment experience with spinal osteosarcoma is limited. The purpose of this study is to report the effect of therapy of primary osteosarcoma of spine by carbon-ion radiotherapy (CIRT) and long-term follow.

Methods

A 70-year-old with primary spinal osteosarcoma who received CIRT underwent combined anterior artificial vertebral body replacement and posterior lumbar fusion (L1–L5) 3 years later.

Results

According to the surgical resection of tumoral lesion, pathological results showed that the intertrabecular space previously filled with tumor cells on the initial biopsy sample now contained necrotic tissue without tumor cells. This means that primary osteosarcoma of the spine was completely eliminated and achieved local control with CIRT, with a 7-year follow-up after the initial treatment.

Conclusions

Carbon ion beam treatment is an effective local treatment for patients with spinal osteosarcoma for whom surgical resection is not a feasible option, especially for elderly patients. However, more patients need to be evaluated over a longer term to assess the curative effect of CIRT.

Barwick KW, Huvos AG, Smith J (1980) Primary osteogenic sarcoma of the vertebral column: a clinicopathologic correlation of ten patients. Cancer 46:595–604. doi:10.1002/1097-0142 CrossRefPubMed

Shives TC, Dahlin DC, Sim FH, Pritchard DJ, Earle JD (1986) Osteosarcoma of the spine. J Bone Joint Surg Am 68:660–668PubMed

Campanacci M, Cervellati G (1975) Osteosarcoma: a review of 345 cases. Ital J Orthop Traumatol 1:5–22PubMed

Tigani D, Pignatti G, Picci P, Savini R, Campanacci M (1988) Vertebral osteosarcoma. Ital J Orthop Traumatol 14:5–13PubMed

Grimer RJ, Carter SR, Tillman RM, Spooner D, Mangham DC, Kabukcuoglu Y (1999) Osteosarcoma of the pelvis. J Bone Joint Surg Br 81:796–802CrossRefPubMed

Kawai A, Huvos AG, Meyers PA, Healey JH (1998) Osteosarcoma of the pelvis. Oncologic results of 40 patients. Clin Orthop Relat Res 348:196–207CrossRefPubMed

Duffaud F, Digue L, Baciuchka-Palmaro M, Volot F, Perles-Daniel C, Garbe L, Favre R (2000) Osteosarcomas of flat bones in adolescents and adults. Cancer 88:324–332CrossRefPubMed

Longhi A, Errani C, Gonzales-Arabio D, Ferrari C, Mercuri M (2008) Osteosarcoma in patients older than 65 years. J Clin Oncol 26:5368–5373. doi:10.1200/JCO.2007.14.9104 CrossRefPubMed

Bielack SS, Wulff B, Delling G, Gobel U, Kotz R, Ritter J, Winkler K (1995) Osteosarcoma of the trunk treated by multimodal therapy: experience of the Cooperative Osteosarcoma study group (COSS). Med Pediatr Oncol 24:6–12. doi:10.1002/mpo.2950240103 CrossRefPubMed

10.

DeLaney TF, Park L, Goldberg SI, Hug EB, Liebsch NJ, Munzenrider JE, Suit HD (2005) Radiotherapy for local control of osteosarcoma. Int J Radiat Oncol Biol Phys 61:492–498. doi:10.1016/j.ijrobp.2004.05.051 CrossRefPubMed

11.

Ozaki T, Flege S, Liljenqvist U, Hillmann A, Delling G, Salzer-Kuntschik M, Jurgens H, Kotz R, Winkelmann W, Bielack SS (2002) Osteosarcoma of the spine: experience of the Cooperative Osteosarcoma Study Group. Cancer 94:1069–1077CrossRefPubMed

12.

Matsunobu A, Imai R, Kamada T, Imaizumi T, Tsuji H, Tsujii H, Shioyama Y, Honda H, Tatezaki S, Working Group for the Bone and Soft Tissue Sarcomas (2012) Impact of carbon ion radiotherapy for unresectable osteosarcoma of the trunk. Cancer 118:4555–4563. doi:10.1002/cncr.27451 CrossRefPubMed

13.

Kamada T, Tsujii H, Tsuji H, Yanagi T, Mizoe JE, Miyamoto T, Kato H, Yamada S, Morita S, Yoshikawa K, Kandatsu S, Tateishi A, Working Group for the Bone and Soft Tissue Sarcomas (2002) Efficacy and safety of carbon ion radiotherapy in bone and soft tissue sarcomas. J Clin Oncol 20:4466–4471. doi:10.1200/JCO.2002.10.050 CrossRefPubMed

14.

Karnofsky DA, Abelmann WH, Craver LF, Burchenal JH (1948) The use of the nitrogen mustards in the palliative treatment of carcinoma. With particular reference to bronchogenic carcinoma. Cancer 1:634–656. doi:10.1002/1097-0142 CrossRef

15.

Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, Carbone PP (1982) Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 5:649–656CrossRefPubMed

16.

Schoenfeld AJ, Hornicek FJ, Pedlow FX, Kobayashi W, Garcia RT, DeLaney TF, Springfield D, Mankin HJ, Schwab JH (2010) Osteosarcoma of the spine: experience in 26 patients treated at the Massachusetts General Hospital. Spine J 10:708–714. doi:10.1016/j.spinee.2010.05.017 CrossRefPubMed

17.

Mankin HJ, Hornicek FJ, Rosenberg AE, Harmon DC, Gebhardt MC (2004) Survival data for 648 patients with osteosarcoma treated at one institution. Clin Orthop Relat Res 429:286–291CrossRefPubMed

18.

Hundsdoerfer P, Albrecht M, Rühl U, Fengler R, Kulozik AE, Henze G (2009) Long-term outcome after polychemotherapy and intensive local radiation therapy of high-grade osteosarcoma. Eur J Cancer 45:2447–2451CrossRefPubMed

19.

Blattmann C, Oertel S, Schulz-Ertner D, Rieken S, Haufe S, Ewerbeck V, Unterberg A, Karapanagiotou-Schenkel I, Combs SE, Nikoghosyan A, Bischof M, Jakel O, Huber P, Kulozik AE, Debus J (2010) Non-randomized therapy trial to determine the safety and efficacy of heavy ion radiotherapy in patients with non-resectable osteosarcoma. BMC Cancer 10:96. doi:10.1186/1471-2407-10-96 CrossRefPubMedPubMedCentral

20.

Okada T, Kamada T, Tsuji H, Mizoe JE, Baba M, Kato S, Yamada S, Sugahara S, Yasuda S, Yamamoto N, Imai R, Hasegawa A, Imada H, Kiyohara H, Jingu K, Shinoto M, Tsujii H (2010) Carbon ion radiotherapy: clinical experiences at National Institute of Radiological Science (NIRS). J Radiat Res 51:355–364CrossRefPubMed

21.

Barendsen GW (1996) RBE-LET relationships for lethal, potentially lethal and sublethal damage in mammalian cells: implications for fast neutron radiotherapy. Bulletin du cancer Radiotherapie 83(Suppl):15s–18sCrossRef

22.

Skarsgard LD (1998) Radiobiology with heavy charged particles: a historical review. Phys Med 14(Suppl 1):1–19PubMed

23.

Ogata T, Teshima T, Kagawa K, Hishikawa Y, Takahashi Y, Kawaguchi A, Suzumoto Y, Nojima K, Furusawa Y, Matsuura N (2005) Particle irradiation suppresses metastatic potential of cancer cells. Cancer Res 65:113–120PubMed

24.

Tamaki T, Iwakawa M, Ohno T, Imadome K, Nakawatari M, Sakai M, Tsujii H, Nakano T, Imai T (2009) Application of carbon-ion beams or gamma-rays on primary tumors does not change the expression profiles of metastatic tumors in an in vivo murine model. Int J Radiat Oncol Biol Phys 74:210–218. doi:10.1016/j.ijrobp.2008.12.078 CrossRefPubMed

25.

Akino Y, Teshima T, Kihara A, Kodera-Suzumoto Y, Inaoka M, Higashiyama S, Furusawa Y, Matsuura N (2009) Carbon-ion beam irradiation effectively suppresses migration and invasion of human non-small-cell lung cancer cells. Int J Radiat Oncol Biol Phys 75:475–481. doi:10.1016/j.ijrobp.2008.12.090 CrossRefPubMed

26.

Matsumoto K, Imai R, Kamada T, Maruyama K, Tsuji H, Tsujii H, Shioyama Y, Honda H, Isu K, Working Group for the Bone and Soft Tissue Sarcomas (2013) Impact of carbon ion radiotherapy for primary spinal sarcoma. Cancer 119:3496–3503. doi:10.1002/cncr.28177 CrossRefPubMed

27.

Imai R, Kamada T, Tsuji H, Tsujii H, Tsuburai Y, S-i Tatezaki (2006) Cervical spine osteosarcoma treated with carbon-ion radiotherapy. Lancet Oncol 7:1034–1035CrossRefPubMed

Title: Carbon-ion radiotherapy of spinal osteosarcoma with long-term follow
Authors: Wei Zhang
Masato Tanaka
Yoshihisa Sugimoto
Tomoyuki Takigawa
Toshifumi Ozaki
Publication date: 01-05-2016
Publisher: Springer Berlin Heidelberg
Published in: European Spine Journal / Issue Special Issue 1/2016
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-015-4202-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Carbon-ion radiotherapy of spinal osteosarcoma with long-term follow

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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